降钙素原检测在新生儿败血症中的临床意义

目的探讨降钙素原（PCT）检测在新生儿败血症中的临床意义。方法将46例败血症新生儿作为观察组，人院时及恢复期行血清PCT及C反应蛋白（CRP）检测，并与同期出生的46例正常新生儿作为对照组进行比较。结果观察组患儿人院时PCT、CRP显著高于对照组（P〈0．05），恢复期降至正常，与对照组相比无明显差异（P〉0．05）；观察组入院时PCT检测的阳性率为93．4％，与CRP阳性率783％相比差异具有统计学意义（P〈0．05）。结论降素钙原检测在新生儿败血症的早期诊断、疗效观察中具有重要的临床应用价值，值得推广。

Clinical significance of procalcitonin detection in neonatal sepsis

Objective To investigate the clinical significance of procalcitonin（PCT） detection in neonatal sepsis. Methods Forty-six sepsis neonates of the observation group received serum PCT and C-reactive protein（CRP） detection at admission and in the recovery phase and were compared to 46 normal neonates of the control group born in the corresponding period. Results The observation group had significantly higher PCT and CRP than the control group at admission（P 〈 0.05）,but decreased to the normal level in the recovery phase and was not significantly different to the control group（P 〈 0.05） ; The positive rate of PCT detection of the observation group at admission was 93.4%,which had statistically significant difference from the 78.3% of CRP positive rate（P 〈 0.05）. Conclusion Procalcitonin detection shows important clinical application value in the early diagnosis and efficacy observation of neonatal sepsis,thereby worthy of promotion.