| 黄芩苷固体脂质纳米粒体外释放研究 |
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| 引用本文： | 黄义,;李新中,;雷鹏,;刘韶,;许利敏. 黄芩苷固体脂质纳米粒体外释放研究[J]. 中国药房, 2009, 0(9): 646-647 |
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| 作者姓名： | 黄义, 李新中, 雷鹏, 刘韶, 许利敏 |
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| 作者单位： | [1]中南大学湘雅医院,长沙市410008; [2]中南大学药学院,长沙市410013 |
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| 基金项目： | 湖南省科技厅科技计划一般项目（05SK3002） |
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| 摘 要： | 目的:研究黄芩苷固体脂质纳米粒的体外释药规律。方法:采用动态透析技术研究黄芩苷固体脂质纳米粒的体外释药性能,并用高效液相色谱法测定黄芩苷含量,以累积释药百分率进行不同模型的拟合。结果:黄芩苷固体脂质纳米粒的释放曲线符合Hixon-crowell方程,t≈3h。结论:黄芩苷固体脂质纳米粒具有良好的缓释作用。
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| 关 键 词： | 黄芩苷 固体脂质纳米粒 体外释放 |
In Vitro Release of Baicalin Solid Lipid Nanoparticles |
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| Affiliation: | HUANG Yi, LI Xin-zhong, LEI Peng, LIU Shao, XU Li-min(Xiangya Hospital of Central South University, Changsha 410008, China) (School of Pharmaceutical Sciences, Central South University, Changsha 410013, China) |
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| Abstract: | OBJECTIVE： To study the in vitro release profile of baicalin solid lipid nanoparticles. METHODS： The in vitro release profile of baicalin solid lipid nanoparticles was studied using dynamic dialysis technology; the content of baicalin was determined by HPLC, and the fitting of different models were performed based on the accumulative drug release percent- ages. RESULTS： The release curve of baicalin solid lipid nanoparticles was in line with the Hixon - crowell equation, with t1/2≈3 h. CONCLUSION： Baicalin solid lipid nanoparticles had satisfactory sustained release efficacy. |
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| Keywords: | Baicalin Solid lipid nanoparticles In vitro release |
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