HPLC法测定氟哌啶醇片中主药的含量

目的:建立以高效液相色谱法测定氟哌啶醇片中主药含量的方法。方法:色谱柱为Diamonsil C18,流动相为0.1mol·L-1磷酸二氢钾(pH3.0)-甲醇(45∶55),流速为1.0mL·min-1,检测波长为248nm,柱温为35℃,进样量为20μL。结果:氟哌啶醇检测浓度的线性范围为0.01～1mg·mL-1(r=0.9999);平均回收率为97.6%(RSD=1.1%)。结论:本方法简便、快速、准确、专属性好,可用于该制剂的质量控制。

Content Determination of Main Compontents in Haloperidol Tablets by HPLC

OBJECTIVE： To develop an HPLC method for determination of the content of the main compontents in haloperidol tablets. METHODS： The samples were determined on Diamonsil C18 column at a column temperature of 35 ℃. The mobile phase consisted of 0.1 mol·L^-1 KA-IPO4 （pH 3.0） -methanol （45 ： 55） at a flow rate of 1.0 mL·min ^-1. The UV detection wavelength was 248nm and the sample size was 20uL. RESULTS： The linear range for haloperidol was 0.01-1 mg·mL^-2 （r = 0.999 9） and its average recovery was 97.6% （RSD = 1.1% ） . CONCLUSIONS： The method was simple, rapid, accurate and specific, and suitable for the quality control of this preparation.