大剂量甲泼尼龙联合巴曲酶注射液治疗突发性耳聋的疗效观察

目的:观察大剂量甲泼尼龙联合巴曲酶注射液治疗突发性耳聋(SD)的疗效。方法:62例66耳SD患者随机分为试验组30例(32耳)与对照组32例(34耳),对照组采用常规药物治疗,试验组在对照组基础上加用大剂量甲泼尼龙。2组用药时间均为12 d,比较其临床疗效。结果:试验组与对照组的总有效率分别为93.75%、76.47%(P<0.05),平均听阈提高分别为(36.37±16.04)、(20.12±14.86)dB(P<0.05)。结论:尽早采用大剂量甲泼尼龙联合巴曲酶注射液治疗SD,可缩短病程,提高疗效。

Therapeutic Efficacy of High- dose Methylprednisolone plus Batroxobin Injection for Sudden Deafness

OBJECTIVE： To evaluate the therapeutic efficacy of high dose Methylprednisolone plus Batroxobin Injection for sudden deafness（SD） . METHODS： 62 SD cases（66 ears） were randomly assigned to receive conventional therapy alone （control group, 32 cases/34 ears） or conventional therapy in combination with high- dose Methylprednisolone（trial group, n - 30 cases/32 ears） for 12 days. The clinical efficacy was compared between the two groups. RESULTS： The total effective rate of the trial group vs. the control group was 93.75% vs. 76.47% （P〈0.05） and the average hearing thresholds were elevated by （36.37± 16.04） dB for trial group vs. （20.12±14.86） dB for control group（P 〈 0.05） . CONCLUSION： Early use of highdose methylprednisolone plus Batroxobin Injection can shorten the course of treatment while enhancing the therapeutic efficacy for SD.