Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities |
| |
Authors: | Xin Nian Li Yu-Juan Li Yan Dai Rong-Ji Meng Wei-Wei Chen Yan Schlappi Michael Deng Yu-Lin |
| |
Institution: | a School of Life Science, Beijing Institute of Technology (BIT), 5 South Zhongguancun Street, Haidian District, Beijing 100081, PR China b Beijing BIT&GY Pharmaceutical R&D Co., Ltd., Beijing 100081, PR China c Marquette University, Milwaukee, WI 53233, USA |
| |
Abstract: | Ethnopharmacological relevanceDragon's Blood from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China), as a traditional Chinese medicinal herb, was shown to have certain antithrombotic effects. A new preparation process was used to extract effective components from Dragon's Blood. A 95% ethanol extract A (EA) and a precipitate B (PB) fraction were obtained and compared. Reliability of the preparation process was validated by pharmacodynamic experiments.Materials and methodsA rat/mouse thrombosis and blood stasis model was developed for this study, and EA and PB effects on thrombosis, platelet functions and blood coagulation activities were analyzed.ResultsIt was observed that the EA fraction had significantly better inhibitory effects than the PB fraction on thrombosis (p < 0.05), platelet aggregation function (p < 0.01) and anticoagulation activity (p < 0.05-0.01).ConclusionsThe results obtained here showed that EA fraction from Dragon's Blood contained pharmacologically effective compounds with antithrombotic effects, partially improving platelet function and anticoagulation activity. |
| |
Keywords: | EA 95% ethanol extract A TCM Traditional Chinese Medicine PLT platelet count FIB fibrinogen APTT activated partial thromboplastin time TXA2 thromboxane A2 ADPNa2 adenosine-5&prime -diphosphate disodium salt dehydrate PB precipitate B IVC inferior vena cava PRP platelet rich plasma ADP adenosine diphosphate PT prothrombin time vWF vonWillebrand factor |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|