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| 用尿药法比较氧氟沙星两种片剂的生物利用度 | |
| 引用本文： | 张华安,张秋霞,魏友霞,张崇道. 用尿药法比较氧氟沙星两种片剂的生物利用度[J]. 中国医院药学杂志, 1993, 0(9) |
| 作者姓名： | 张华安 张秋霞 魏友霞 张崇道 |
| 作者单位： | 西安医科大学第一附属医院药剂科710061，西安医科大学第一附属医院药剂科710061，西安医科大学第一附属医院药剂科710061，西安医科大学药学系 92年毕业生 |
| 摘 要： | 本文用尿药浓度法测定六名志愿者单剂量口服国产、进口两种氧氟沙星片剂的尿药浓度,结果表明:国产与进口两种片剂具有相同的药动学特征及生物等效性。其药动学参数分别为:k(h~(-1)):0.1185、0.1180;T_(1/2)(h):5.94、6.11;(?)—24(mg):174.66、167.79;排泄率:87.33%、83.89% |
| 关 键 词： | 氧氟沙星 尿药浓度法 生物利用度 |
Comparison of bioavailability between two kinds of oflaxacin tablet by urine drug determination |
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| Abstract: | The concentration of OFLX in urine of six heaithy volunteers was determined after the tablets of foreign product anddomestic product were orally given by single-dose.The results showed that both products had same pharmacokinetic parametersand bioequivalence.The pharmacokinetic parameters were K(hr~(-1)):0.1185;0.1180;T 1/2(hr):5.94,6.11;Xu~(0.24)(mg):174.66,167.69;and eliminative rate:87.33%,83.89%. |
| Keywords: | ofloxacin drug level in urine bioavailability |
| 本文献已被 CNKI 等数据库收录！ | |