阿立哌唑与利培酮治疗女性首发精神分裂症患者血浆催乳素水平的比较

目的：比较阿立哌唑与利培酮治疗女性首发精神分裂症患者的疗效和血浆催乳素水平。方法：选择接受阿立哌唑和利培酮治疗的女性首发精神分裂症患者各60例，于治疗前和治疗8周后分别评估患者PANSS量表，并检测患者血浆催乳素水平。结果：治疗8周后阿立哌唑与利培酮组相比，PANSS减分率差异无显著性（49．79±23．48vs．63．3±22．66，p〉0．05）。利培酮治疗组血浆催乳素水平变化值高于阿立哌唑治疗组（26．92±9．48vs．-25．25±8．07，P〈0．001）。利培酮治疗8周血浆催乳素水平增加与疾病严重程度、药物治疗剂量、疗效及体重变化等变量无显著相关，而与治疗前后血浆催乳素水平显著相关（r=0.41，r=0．79，p〈0．01）。结论：阿立哌唑治疗精神分裂症疗效与利培酮相当，但较少引起血浆催乳素水平变化。

Comparison of effects on plasma prolactin levels between aripiprazole and risperidone

Objective： To compare the effects on plasma prolactin （PRL） level and its correlation with clinical characteristics between aripiprazole and risperidone in female schizophrenia at frrs-onset stage. Method： One-hundred and twenty female patients with first-onset schizophrenia were randomly divided into aripiprazole group （n = 60） and risperidone group （n = 60） for eight therapeutic weeks. The positive and negative syndrome scale （PANSS） was evaluated before and after therapy 8 weeks. The plasma PRL level was measured by radioim- munoassay before and after 8-week therapy. Results： There was no significant difference between the reduced rate of total scores of PANSS after 8 weeks in aripiprazole group and that in risperidone group （49.79＋23.48 v.s. 63.30：1：22.66, p〉0.05）. The plasma PRL level increased after 8-week risperidone therapy, but reduced after aripiprazole therapy （26.92＋9.48 v.s. -25.25＋8.07, P〈0.001）. There were significant correlations between the dispersion of plasma PRL levels and the PRL levels before and after after 8-week therapy （r=0.41 ,r=0.79,p〈0.01, respectively）. No significant correlations were found between the dispersion of plasma PRL level and the reduction of total PANSS score, weight gain, dosage of drugs or other characteristics （/〉〉0.05）. Conclusion： Aripipazole is as effective as risperidone in the therapy of patients with first-onset schizophrenia. However, Aripipazole with less influence on plasma PRL level, which differentiate from risperidone and has no relationship with clinical characteristics.