| ANA、抗ds—DNA、抗ENA多肽抗体谱联合检测对SLE的临床诊断价值 |
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| 引用本文： | 李义德,张玉蓉,王刚,王利新. ANA、抗ds—DNA、抗ENA多肽抗体谱联合检测对SLE的临床诊断价值[J]. 宁夏医学杂志, 2001, 23(11): 646-647 |
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| 作者姓名： | 李义德 张玉蓉 王刚 王利新 |
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| 作者单位： | 宁夏医学院附属医院中心实验室 |
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| 摘 要： | 目的 探讨ANA、抗ds-DNA、抗ENA多肽抗体谱联合检测在诊断SLE病人中的应用。方法 ANA、抗ds-DNA采用间接免疫荧光法；ENA多肽抗体采用免疫印迹法（IBT）。结果 检测167例SLE患者，ANA阳性率为86．8％；抗ds-DNA阳性率为67．1％；抗ENA多肽抗体阳性率为71．9％，其中18例ANA为阴性而抗ENA多肽抗体为阳性。结论 ANA、抗ds-DNA、抗ENA多肽抗体谱联合检测在SLE诊断中具有互补性，并能提高检出率。对SLE的诊断分型、治疗预后均有重要的临床价值。
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| 关 键 词： | 抗核抗体 ANA ENA多肽抗体 抗ds－DNA抗体 系统性红斑狼疮 SLE |
| 文章编号： | 1001-5949(2001)11-0646-02 |
| 修稿时间： | 2001-03-05 |
Clinical diagnostic value of collective determination of ANA,anti-ds-DNA,anti-ENA polypeptide antibody spectrum for SLE |
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| LI Yi-de,ZHANG Yu-rong,Wang Gang,et al.. Clinical diagnostic value of collective determination of ANA,anti-ds-DNA,anti-ENA polypeptide antibody spectrum for SLE[J]. Ningxia Medical Journal, 2001, 23(11): 646-647 |
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| Authors: | LI Yi-de ZHANG Yu-rong Wang Gang et al. |
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| Abstract: | Objectives To investigate the application of collective determination of ANA,anti-ds-DNA polypeptide antibody spectrum in diagnosis of SLE patients.Methods To test ANA,anti-ds-DNA by indirect immunofluorescence,while to test ENA polypeptide antibody spectrum by immunolabelling technique(IBT).Results In 167 SLE cases tested,ANA positive rate was 86.8%;anti-ds-DNA postitive rati was 67.1%;and anti-ENA polypeptide antibody spectrum positive rate was 71.9%.Among the total,18 cases had negative ANA but positive anti-ENA polypeptide antibody spectrum.Conclusions In diagnosing SLE,collective determination of ANA,anti-ds-DNA,anti-ENA polypeptide antibody spectrum can complement each other,upgrade the detectable rate and have the significant clinical value in diagnostic classification and prognosis of the diseases. |
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| Keywords: | Antinudear antibodies Potypeptides |
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