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| HPLC法测定复方酮康唑乳膏的含量 | |
| 引用本文： | 高平,朱江. HPLC法测定复方酮康唑乳膏的含量[J]. 中国药师, 2009, 12(2) |
| 作者姓名： | 高平 朱江 |
| 作者单位： | 随州市药品检验所,湖北随州,441300 |
| 摘 要： | 目的:建立RP-HPLC法测定复方酮康唑乳膏(皮康王)中的酮康唑、丙酸氯倍他索的含量。方法:用THERO Hylicerm ODS C_(18)(250mm×4.6mm,5μm),流动相为甲醇-0.02mol·L~(-1)磷酸二氢钾溶液(72:28)(用氨水调pH到7.2),流速1. 0ml·min~(-1),检测波长240nm。结果:酮康唑和丙酸氯倍他索的线性范围分别为2.5～25.0μg(r=0.999 9)和0.07～0.66μg(r =0.999 8),平均回收率分别为100.0%(RSD 0.1%)和99.6%(RSD 0.4%)(n=6)。结论:方法专属和准确,可作为复方酮康唑乳膏的质量控制。 |
| 关 键 词： | 高效液相色谱法 酮康唑 丙酸氯倍他索 |
Determination the Contents of Ketoconazole and Clobetasol Propionate in Compound Ketoconazole Cream by RP-HPLC |
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| Gao Ping,Zhu Jiang. Determination the Contents of Ketoconazole and Clobetasol Propionate in Compound Ketoconazole Cream by RP-HPLC[J]. China Pharmacist, 2009, 12(2) | |
| Authors: | Gao Ping Zhu Jiang |
| Affiliation: | Gao Ping; Zhu Jiang(Suizhou Institute for Drag Control; Hubei; Suizhou 441300; China); |
| Abstract: | Objective:To establish a RP-HPLC method for determination the contents of ketoconazole and clobestasol propionate in compound ketoconazole cream.Method:The thero hylicerm ODS-C_(18) column(250mm×4.6mm,5μm) was used,the mobile phase consisted of methanol -0.02mol·L~(-1) potassium dihydrogen phosphate solution(72:28),the flow rate was 1.0 ml·min~(-1),the detection wavelength was 240 nm.Result:The linear ranges of ketoconazole and clobetasol propionate were 2.5-25μg(r=0.999 9) and 0.07 -0.66μg(r=0.999 8),the a... |
| Keywords: | RP-HPLC Ketoconazole Clobetasole propionate |
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