二术二陈汤加减对脾虚痰湿证多囊卵巢综合征患者的调理作用

目的:观察二术二陈汤加减对脾虚痰湿证多囊卵巢综合征(PCOS)代谢的调节效果,以及对脂肪细胞因子的影响.方法:将140例患者按随机数字表法分为对照组和观察组各70例.两组均口服盐酸二甲双胍片,500 mg/次,3次/d.对照组口服越鞠二陈丸,0.5 g/次,3次/d;观察组内服二术二陈汤加减,l剂/d;两组疗程均为24...

Regulatory Effect of Modified Erzhu Erchentang on Patients with Polycystic Ovary Syndrome and Spleen Deficiency and Phlegm Dampness

Objective: To observe the regulatory effect of modified Erzhu Erchentang on metabolization of polycystic ovary syndrome(PCOS)with spleen deficiency and phlegm dampness syndrome.Method: Patients 140 cases were divided into control group and observation group. Both groups were given metformin hydrochloride tablets,500 mg/time,3 times/day. Control group was given Yuejun Erchen pills,0.5 g/time,3 times/day,while observation group was given modified Erzhu Erchentang,1 dose/day. The course of treatment lasted for 24 weeks. Before and after treatment,levels of fasting blood glucose(FBG),fasting insulin(FINS),glycosylated hemoglobin Alc(HbA1c),2-hour postprandial blood glucose(2 h PG),blood lipid,waist circumference(WC),body mass index(BMI),waist hip ratio(WHR),luteinizing hormone(LH),follicle stimulating hormone(FSH),serum testosterone(T),estradiol(E2),dehydroepiandrosterone sulfate(DHEAS),sex hormone binding globulin(SHBG),leptin(LP),adiponectin(APN),resistin,visfatin and tumor necrosis factor-α (TNF-α) were detected. Homeostasis model assessment insulin resistance(HOMA-IR)was calculated,modified Erzhu Erchentang was scored,and recovery of menstruation and ovulation and ovarian volume were recorded. Result: Levels of FBG,2 h PG,HbA1c,FINS,HOMA-IR,triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),LH,FSH,T,E2,DHEAS, LP, resistin, visfatin and TNF-α in observation group were lower than those in control group(P<0.01),and levels of BMI,WC and WHR were lower than those of control group(P<0.05). And levels of high-density lipoprotein cholesterol(HDL-C), SHBG and APN were higher than those in control group(P<0.01). Score of modified Erzhu Erchentang was lower than that in control group(P<0.01),and ovarian volume was smaller than that in control group(P<0.01). The normal rate of BMI was 49.23%(32/65),which was higher than 30.30%(20/66)in control group(χ²=5.151,P<0.05). The normal rate of blood lipid was 93.85%(61/65),which was higher than 81.82 %(54/66)in control group(χ²=4.418,P<0.05). The normal rate of blood glucose was 96.92%(63/65),which was higher than 86.36%(57/66)in control group(χ²=4.474,P<0.05). Conclusion: In addition to adipocytokines,modified Erzhu Erchentang could regulate adipokines of patients of PCOS with spleen deficiency and phlegm dampness, improve glucose, lipid metabolism and overweight,adjust endocrine hormone,reduce clinical symptoms and improve ovarian structure,so as to create conditions for conception.