抗甲状腺球蛋白抗体对妇女甲状腺乳头状癌发病的影响

目的 探讨抗甲状腺球蛋白抗体(TgAb)对妇女甲状腺乳头状癌发病中的影响.方法 选取2018年2月至2019年12月间上海市宝山区罗店医院收治的72例女性甲状腺乳头状癌患者为研究组,选取同期行手术治疗并经病理结果 明确的80例良性甲状腺结节女性患者为对照组.比较两组患者抗甲状腺球蛋白抗体的差异和甲状腺乳头状癌患病风险与...

Effect of antithyroglobulin antibody on the incidence of papillary thyroid carcinoma in women

Objective To explore the effect of antithyroglobulin antibody on the incidence of papillary thyroid carcinoma in women. Methods A total of 72 female patients with papillary thyroid carcinoma admitted to Luodian Hospital of Shanghai Baoshan District from February 2018 to December 2019 were selected as the study group. Meanwhile,80 female surgical treatment-na? ve patients who were confirmed with benign thyroid nodules by pathological results at the same time were selected as the control group. The differences in anti-thyroglobulin antibody between the two groups were compared and the correlation between the risk for papillary thyroid carcinoma and anti-thyroglobulin antibody was analyzed. Results Body mass index( BMI),Tg Ab and thyroid stimulating hormone( TSH) were significantly higher in the study group than in the control group( all P < 0. 05). The size of nodules in diameter was lower in the study group than in the control group( P < 0. 05). There was no statistical difference in age,medical history and history of drinking between the two groups( P > 0. 05). Positive rate of Tg Ab was higher in patients with microcarcinoma and non-microcarcinoma in the study group than in the control group( P > 0. 05). There was no significant difference in positive rate of Tg Ab between patients with microcarcinoma and patients with non-microcarcinoma( P > 0. 05). Positive rate of Tg Ab was higher in group A than in group( P > 0. 05). Multiple linear regression showed that BMI,TSH and Tg Ab were positively associated with the occurrence of papillary thyroid carcinoma in women( all P < 0. 05). However,the diameter of nodule was negatively associated with the risk for papillary thyroid carcinoma. Conclusion Anti-thyroglobulin antibody was closed associated with the morbidity of papillary thyroid carcinoma and it was an independent risk factor for papillary thyroid carcinoma in women. Therefore it can provide strong theoretical basis for definite diagnosis of papillary thyroid disease in women.