| 复方桂枝茯苓丸对脑缺血再灌注损伤大鼠NOS、Na＋^-K^＋-ATPase的影响 |
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| 引用本文： | 张建荣,任月朗,邢小燕.复方桂枝茯苓丸对脑缺血再灌注损伤大鼠NOS、Na＋^-K^＋-ATPase的影响[J].四川中医,2009,27(4):13-15. |
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| 作者姓名： | 张建荣 任月朗 邢小燕 |
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| 作者单位： | 张建荣,Zhang Jianrong(陕西中医学院,陕西,西安,712046);任月朗,Ren Yuelang(西安北环医院,陕西,西安,710032);邢小燕,Xing Xiaoyan(咸阳职业技术学院医学系,西安,咸阳,712000)
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| 摘 要： | 目的：观察复方桂枝茯苓丸对脑缺血再灌注损伤（CRI）大鼠一氧化氮合酶（NOS）、Na^＋-K^＋-ATP酶（Na^＋-K^＋-ATPase）的影响。方法：用结扎双侧颈总动脉45min后再通法，制备CRI大鼠模型，用复方桂枝茯苓丸、血塞通治疗，给药2周，检测血清与脑匀浆NOS活性、脑匀浆Na^＋-K^＋-ATPase活性变化。结果：复方桂枝茯苓丸能降低CRI大鼠血清与脑匀浆NOS活性，升高大鼠脑匀浆Na^＋-K^＋-ATPase活性。结论：复方桂枝茯苓丸对CRI大鼠具有治疗作用。
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| 关 键 词： | 复方桂枝茯苓丸 CRI NOS Na^+-K^+-ATPase |
Compound Guizhifuling Pill on NETS, Na+ - K+ - ATPase of Cerebral iscbemia- reperfusion Injury Rats |
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| Zhang Jianrong,Ren Yuelang,Xing Xiaoyan.Compound Guizhifuling Pill on NETS, Na+ - K+ - ATPase of Cerebral iscbemia- reperfusion Injury Rats[J].Journal of Sichuan of Traditional Medicine,2009,27(4):13-15. |
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| Authors: | Zhang Jianrong Ren Yuelang Xing Xiaoyan |
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| Institution: | Zhang Jian-tong,Ren Yuelang,Xing Xiaoyan(1.Shaanxi College of Traditional Chinese Medicine Xi＇an Shanxi 712046, China;2. Xi＇ an Beihuan Hospital,Xi＇ an Shangxi 710032, China;3. Medical Department, Xianyang Vocational ＆ Technical College,Xianyang Shangxi 712000, China) |
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| Abstract: | Objective： To investigate compound Guizhifuling pills on nitric oxide （NOS） and Na ＋ - K ＋ - ATPase of cerebral is-chemia- repeffusion injury （CRI） rats. Methods： CRI rat model was established by ligafion of bilateral carotid artery for 45 minutes. Rats were administered with compound Guizhifuling pills and Xuesaitong for 2 weeks. Then, changes of NOS and Na ＋ - K ＋ - ATPase activities in brain homogenate were observed. Results： Compound Guizhifuling pills reduced NOS activity in serum and brain homogenate of CRI rats, and increased Na^＋ - K^＋ - ATPase activities in brain homogenate of CRI rats. Conclusion： Compound Guizhifuling pill has certain therapeutic effect on CPd rats. |
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| Keywords: | CRI NOS Na -K -ATPase |
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