我院2012年药品不良反应报告分析

目的分析该院2012年药品不良反应(adverse drug reactions,ADR)发生的原因与特点,为临床合理用药提供依据。方法对该院2012年上报的120例ADR报告,采用回顾性分析,通过Excel表格,按照引起药品不良反应的给药途径、药品种类、不良反应涉及的系统与主要临床表现等进行统计和分析。结果静脉给药方式ADR发生率最高(90%);抗肿瘤药物引起的ADR居首(35%),其次为抗感染药(15%);临床表现以胃肠道系统损害最常见(35%);ADR主要由药师和临床药师报告(98%)。结论应加强ADR监测和报告,促进临床合理用药,确保患者用药的安全性。

ADR cases report in our hospital in 2012

Objective To analyze the causes and features of adverse drug reactions （ADR）in our hospital.Methods 120 ADR case reports collected in 2012 were analyzed statistically in respect of the route of administration,category of the drugs,systems in-volved,and clinical manifestation.Results The ADR incidence rate caused via intravenous dip （90%）was the highest.The ADR incidence rate was 35%,which was caused mainly by anti-tumor drugs.The ADRs were chiefly characterized by gastrointestinal le-sions （35%）.The ADRs were mainly reported by pharmacists and clinical pharmacists.Conclusion ADR monitoring and repor-ting should be strengthened to promote the rational use of drugs in clinic.