ER、PR在子宫腺肌病组织中的表达及临床意义研究

目的:探讨子宫腺肌病组织中雌激素受体(ER)、孕激素受体(PR)的表达及其临床意义。方法:应用免疫组化SP法检测40例子宫腺肌病患者子宫标本的在位内膜、异位内膜、腺肌病灶周边组织、正常肌层组织及40例正常子宫内膜组织正位内膜中ER、PR的表达。结果:子宫腺肌病患者异位内膜腺上皮ER、PR的阳性表达率分别为82.5%、80%,均低于其在在位内膜组织中的表达率97.5%、95%(P<0.05),而高于正常子宫内膜组织中的表达率57.5%、60%(P<0.05);子宫腺肌病病灶周边组织ER、PR的阳性表达率分别为47.5%、52.5%,均高于正常肌层组织的表达率25%、27.5%(P<0.05),而低于异位内膜组织的表达率82.5%、80%(P<0.05)。结论:子宫腺肌病是性激素依赖性疾病,其发病可能与ER、PR有关;子宫腺肌病病灶周边组织ER、PR的高水平表达可能是子宫腺肌病复发的重要原因之一。

The study of expression and clinical significance of estrogen receptor(ER)and progesterone receptor(PR)proteins in adenomyosis

Objective:To investigate the expression and clinical significance of estrogen receptor (ER) and progesterone receptor (PR) proteins in adenomyosis. Methods:Immunohistochemical staining was used to detect the ER and PR proteins expression levels in eutopic endometrium ,ectopic endometrium,para-adenomyosis tissues and normal muscle tissue specimens of 40 cases with adeno- myosis and 40 cases with nomal endometrium. Results:The positive rate of ER and PR proteins in ectopic endometrium was lower than that in eutopic endometrium(82.5% vs 97.5%,80% vs 95%) but higher than that in nomal endometrium(82.5% vs 57.5%,80% vs 60%) (P<0.05 respectively);The positive rate of ER and PR proteins in para-adenomyosis tissues was lower than that in ectopic endometrium (47.5% vs 82.5%,52.5% vs 80%) but higher than that in nomal muscle tissues(47.5% vs 25%,52.5% vs 27.5%) (P<0.05 respectively). Conclusions:Adenomyosis is an estrogen-dependent disease and its pathogenesis is possablely concerned with ER and PR, and the recurrence of adenomyosis mainly resultes from the higher expression of ER and PR in rudimental and surrounding focus tissues.