全髋关节置换术中骨水泥对老年患者凝血功能的影响

目的 探讨全髋关节置换术中骨水泥对老年患者凝血功能的影响.方法 对2004年2月至2005年8月34例行骨水泥型全髋关节置换术患者的凝血功能相关指标进行检测,包括血浆凝血酶原时间(PT)、活化的部分凝血酶原时间(APTT)、血浆纤维蛋白原(FIB)及鱼精蛋白副凝固实验(3P试验),分别于注入骨水泥前5 min、注入骨水泥后30 min及3 h各检测1次.所有数据进行统计学处理.结果 注入骨水泥后30 min PT值较注入前5 min显著缩短(P＜0.05);而注入骨水泥后3 h PT值与注入后30 min比较,显著回升(P＜0.05).FIB含量在注入骨水泥后30 min较注入前5 min明显增高(P＜0.05);注入骨水泥后3 h与注入后30 min比较差异有统计学意义(P＜0.05).3P试验阳性率,注入骨水泥后30 min与注入前5 min比较差异有统计学意义(P＜0.05).APTT在该实验中影响不太明显,注入骨水泥3 h后各项指标基本恢复.结论 全髋关节置换术中注入骨水泥30 min后PT缩短,FIB增高,3P试验的阳性率升高,但在3 h后骨水泥对这些指标的影响基本消除,提示注入骨水泥后的3 h内是监测病情的重要时段,在注入骨水泥后,老年患者凝血系统虽有高凝倾向,但各相关指数仍在正常范围内.Abstract：Objective To assess the effects of bone cement implantation on coagulation functions during the total hip arthroplasty in elderly patients. Methods Thirty-four patients admitted to our hospital between February 2004 and August 2005 involved in this study. The relative parameters were observed in all patients, including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and plasma protamine paracoagulation test (3P test). Blood samples were measured 5 minutes before, 30 minutes and 3 hours after bone cement implantation. All data were analyzed with Medical Statistics Software. Results PT significantly decreased at 30 minutes after bone cement implantation, compared with 5 minutes before implantation ( P ＜ 0. 05), and significantly recovered at 3 hours after implantation (P ＜ 0.05). FIB significantly increased at 30 minutes after implantation compared with 5 minutes before implantation ( P ＜ 0.05), and significanlty decreased again at 3 hours after implantation (P ＜ 0.05 ). A higher rate of positive results in 3P test was observed at 30 minutes after implantation compared with 5 minutes before implantation ( P ＜ 0.05 ). There was no significant difference in APTT before and after implantation. Conclusions PT significantly decreased at 30 minutes after bone cement implantation, and FIB or positive rate of 3P test increased, but these parameters recovered at 3 hours after implantation. It showed we must monitor patients in 3 hours after implantation. And bone cement shows a tendency to activate blood coagulation, especially in elderly patients, but the relative indexes are still in normal range.

Effects of bone cement on coagulation functions during total hip arthroplasty in elderly patients

Arthroplasty Total hip arthroplasty Methylmethacrylates Blood coagulation factors