| 海门市原发性肝细胞癌高发危险因素的队列研究 |
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| 引用本文： | 郁新森,黄培新,秦健,王兰萍,钱雪峰,江建华,唐锦高,林文尧.海门市原发性肝细胞癌高发危险因素的队列研究[J].中国预防医学杂志,2006,7(4):241-243. |
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| 作者姓名： | 郁新森 黄培新 秦健 王兰萍 钱雪峰 江建华 唐锦高 林文尧 |
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| 作者单位： | 1. 海门市疾病预防控制中心,江苏,226100
2. 江苏省海门市卫生局 |
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| 摘 要： | 目的探讨海门市原发性肝细胞癌（HCC）高发的主要危险因素，为HCC防制决策提供依据。方法1993年在HCC高发区海门市建立了一支83794人的HCC研究队列，对每一研究对象进行一项流行病学调查，并采集外周静脉血标本作相关检测，每年随访1次，至2001年终止。运用COX比例风险模型对HBsAg、肝炎感染史、HCC家族史、职业史、饮酒史、饮茶史、吸烟史、饮水类型、主食类型等9个变量在HCC发生中的作用作了分析。结果HBsAg（＋）是海门市HCC高发的最主要危险因素（男性HR=22.3，女性HR=37．2）。结论HBV感染，HCC家族史及职业均为HCC高发的危险因素。
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| 关 键 词： | 肝细胞癌 危险因素 COX模型 队列研究 |
| 收稿时间： | 11 16 2005 12:00AM |
| 修稿时间： | 2005年11月16 |
A Cohort Study on Risk Factors of Hepatocellular Carcinoma in Haimen City |
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| YU Xin - sen, HUANG Pei - xin, QIN Jian,et al..A Cohort Study on Risk Factors of Hepatocellular Carcinoma in Haimen City[J].China Preventive Medicine,2006,7(4):241-243. |
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| Authors: | YU Xin - sen HUANG Pei - xin QIN Jian |
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| Institution: | Haimen Center of Disease Prevention and Control, Haimen 226100, China |
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| Abstract: | Objective To explore the main risk factors of Hepatocellular carcinoma(HCC)in Haimen and provid some evidence for decision-making of HCC control. Methods A study cohort of 83794 subjects enrolled was conducted in the areas with high HCC prevalence of Haimen in Jiangsu province.An epidemiological survey including peripheral blood sample were couducted in 1993.The cohort was followed up once a year from 1993 to 2001.The influence of 9 variables of risk factors includijng HBsAg,hepatitis infection history,HCC family history,occupation history,alcohol history,tea and smoking history,type of drinking water and staple food were analysed with COX proportional hazard model. Results The important risk factor of HCC in Haimen is HBsAg(+).hrS:22.3 for male and 37.2 for female. Conclusion |
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| Keywords: | HCC Risk factors COX model Cohort study |
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