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| 美丽红豆杉枝叶中抗肿瘤活性成分的提取与分离 | |
| 引用本文： | 吴绵斌,马淑桢. 美丽红豆杉枝叶中抗肿瘤活性成分的提取与分离[J]. 中药材, 2006, 29(4): 329-331 |
| 作者姓名： | 吴绵斌 马淑桢 |
| 作者单位： | 浙江大学材化学院生物工程研究所,浙江,杭州,310027 |
| 基金项目： | 浙江省重大项目中药产业化项目 |
| 摘 要： | 以美丽红豆杉的枝叶为原料,采用一种新的方法提取和分离用以合成高效抗癌药紫杉醇所需的前体———10-脱乙酰巴卡亭Ⅲ(10-DABⅢ),并对10-DABⅢ的提取、分离、纯化条件进行了优化筛选。采用该工艺方法得到的10-DABⅢ晶体纯度可达91%,得率也在70%以上,从而证实了该工艺路线在生产上是可行的。 |
| 关 键 词： | 美丽红豆杉 抗肿瘤 紫杉醇 10-脱乙酰巴卡亭Ⅲ |
| 文章编号： | 1001-4454(2006)04-0329-03 |
| 收稿时间： | 2005-12-14 |
| 修稿时间： | 2005-12-14 |
The Extraction and Separation of An Active and Available Component from Taxus mairei |
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| WU Mian-bin,MA Shu-zhen. The Extraction and Separation of An Active and Available Component from Taxus mairei[J]. Journal of Chinese medicinal materials, 2006, 29(4): 329-331 | |
| Authors: | WU Mian-bin MA Shu-zhen |
| Affiliation: | Bioengineering Institute, College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China |
| Abstract: | To study on the 10-deacetyl baccatin III extract from the leaves and branches of Taxus mairei. A new method was proposed to extract and purify 10-DAB III, which was adopted as the parent nucleus of the high efficacious antitumour drug-taxol and docetaxel in the compositive synthesis. Optimization selection was also made in the extraction and purification conditions of taxol. The purity quotient of 10-DAB III obtained via this technics could reach 91%, with the yield above 70%. It has been testified that the technics was feasible in industrial practice. |
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