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| VP-16对Tca8113的作用及维拉帕米增效作用的研究 | |
| 引用本文： | 赵峰,焦艳,李宁毅. VP-16对Tca8113的作用及维拉帕米增效作用的研究[J]. 泰山医学院学报, 2007, 28(3): 197-199 |
| 作者姓名： | 赵峰 焦艳 李宁毅 |
| 作者单位： | 1. 泰山医学院附属泰安医院,山东,泰安,271000 2. 青岛大学医学院附属医院,山东,青岛,266003 |
| 摘 要： | 目的在实验室条件下观察VP-16对舌癌细胞株Tca8113的生长抑制作用及维拉帕米是否能增强VP-16对肿瘤细胞的抗癌活性。方法采用MTT法研究VP-16对Tca8113的细胞毒性作用,并尝试加入维拉帕米,评价其对VP-16的影响作用。结果VP-16可显著抑制舌癌细胞株Tca8113的生长,维拉帕米本身对Tca8113细胞的生长抑制作用较小,5 mg/L维拉帕米预作用1 h可明显提高VP-16的作用效果。结论VP-16对舌癌细胞株Tca8113有良好的生长抑制作用。维拉帕米对VP-16有化疗增敏作用。 |
| 关 键 词： | 维拉帕米 细胞培养 化疗增敏剂 |
| 文章编号： | 1004-7115（2007）03-0197-03 |
| 收稿时间： | 2006-12-11 |
| 修稿时间： | 2006-12-11 |
Study of the VP-16''''s effect on Tca8113 cells and Intensification effect of verapamil |
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| ZHAO Feng,JIAO Yan,LI Ning-yi. Study of the VP-16''''s effect on Tca8113 cells and Intensification effect of verapamil[J]. Journal of Taishan Medical College, 2007, 28(3): 197-199 | |
| Authors: | ZHAO Feng JIAO Yan LI Ning-yi |
| Abstract: | Objective:To observe the influence of VP-16 on Tca8113,the cells of carcinoma of tongue,and the enhancement effect of verapamil in the environment of the laboratory,.Methods: The VP-16's effect on Tca8113 cells by MTT was studied and attempt was made to combine verapamil and VP-16 on Tca8113 cells to evaluate the influence of verapamil on VP-16.Results: VP-16 could markedly inhibit the growth of Tca8113.Verapamil in itself could not inhibit the growth of Tca8113 cells.5mg/l verapamil performed for 1h in advance could increase the effect of VP-16.Conclusion: VP-16 can markedly inhibit the growth of Tca8113 cells,and verapamil can obviously intensify the VP-16 effect. |
| Keywords: | VP-16 |
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