Toll样受体与皮肤抗感染免疫

天然免疫分子Toll样受体是一个广泛存在于昆虫、脊椎动物和植物中序列高度保守而古老的家族。它们在天然免疫中可发挥重要的抗感染免疫功能,并与免疫耐受、特异性抗感染免疫,以及一些疾病具有相关性。研究Toll样受体在皮肤组织中识别和抵御常见的几种细菌、病毒及真菌过程中的机制,通过对Toll样受体及其整个系统的认识将为防治各种皮肤感染性疾病开辟广阔前景。

Toll-like Receptors and Anti-infective Immunity in Skin

Toll-like receptors(TLRs) are a kind of innate immunity receptor and belong to an archaic and highly conservative receptor family. They express widely in insects, vertebrates and plant cells. They are crucial participants in the innate immune responses, and are closely related to immunologic tolerance, specific anti-infective immunity and some other diseases. This article reviews the mechanisms of the recognition of and defense against some conventional bacteria, viruses and fungi by Toll-like receptors. The understanding of Toll-like receptors and TLR signaling system will lay a broad way to prevent and treat various infectious dermatoses.