原因不明习惯性流产患者自身抗体的研究

目的 通过对原因不明习惯性流产（ＨＡ）患者进行多项自身抗体的筛查,研究了ＨＡ与自身抗体的关系。方法 ６９例原因不明ＨＡ患者为研究组,其中原发性ＨＡ５１例（原发性ＨＡ）继发性ＨＡ１８例（继发性ＨＡ组）３０例健康育龄妇女为对照组,对３组患者采用酶联免疫吸会法检测血清抗心磷脂抗体,抗单链及双链ＤＮＡ抗体,采用Ｈｅｐ－２细胞间接荧光法筛查抗核抗体,采用间接荣光法检测抗平滑肌,抗心肌及抗线粒体抗体,对７种可

The study of autoantibodies in women with habitual abortion of unknown etiology

OBJECTIVE: To evaluate the relationship between habitual abortion of unknown etiology and autoantibodies. METHODS: IgG and IgA antibodies against cardiolipin, specific antinuclear double-stranded DNA and single-stranded DNA were measured by enzyme linked immunosorbent assay (ELISA). Antinuclear antibody, smooth muscle antibody, antimitochondrial antibody and antiheart muscle antibody were performed by indirect immunofluorescence assay. Antiextractable nuclear antigen's antibodies were determined by immunodiffusion assay. RESULTS: Most women with habitual abortion of unknown etiology showed higher incidence of antibodies to cardiolipin, nuclear, smooth muscle compared with normal multigravida control (P < 0.05). CONCLUSIONS: These results indicate that most women with habitual abortion of unknown etiology have a higher level of autoreactivity, which may affect the course of pregnancy. The incidence of antismooth muscle antibody in women with habitual abortion of unknown etiology is also increased compared with normal multigravida control.