叶酸及其代谢在宫颈癌中的研究进展

叶酸又名蝶酰谷氨酸,其本身并没有生理功能,需要在机体内进行一系列的代谢和转化后才能发挥作用,是参与一碳代谢的关键营养素,在基因合成修复和DNA甲基化中起着重要作用,因此被认为与癌症的发生发展有关.叶酸缺乏和代谢障碍可以作为一个解释宫颈癌多因素致病理论的新角度.但目前叶酸和宫颈癌的相关机制研究尚处于初步阶段,尚需进一步的...

Research Progress of Folic Acid and Its Metabolism in Cervical Cancer

Folic acid,also known as pteroyl glutamate,has no physiological function,which needs a series of metabolism and transformation in the body to play biological role.It is an essential nutrient involved in the one-carbon metabolism pathway,which plays a critical role in the synthesis and repair of genes and DNA methylation,so it is considered to be related to the occurrence and development of cancer.Folic acid deficiency and metabolic disorders could be a new angle to explain the multifactorial pathogenic theory of cervical cancer.However,the research on the related mechanisms of folic acid and cervical cancer is unclear,and further research is needed to clarify the molecular mechanism of folic acid deficiency and metabolic disorders in the occurrence and development of cervical cancer.Folic acid has made significant progress in the prevention,diagnosis and treatment of cervical cancer in recent years,such as the exploration of folic acid supplementation or fortification on the prevention and treatment of cervical lesions,new cervical screening method based on the biochemical properties of folic acid,and novel targeted drugs modified or functionalized by folic acid.This article reviews the research progress of folic acid and its metabolism in cervical cancer.