DNA酶1样蛋白3基因及编码蛋白在系统性红斑狼疮中的研究进展

遗传因素为系统性红斑狼疮(SLE)发病机制中的重要环节。SLE致病位点多态性、编码蛋白功能改变会导致B细胞异常,产生大量炎症因子和特异性自身抗体,最终出现B细胞对DNA和(或)染色质的耐受性丧失。DNA酶1样蛋白3(DNASE1L3)基因和编码蛋白Dnase1L3在降解DNA凋亡微粒及清除血清抗双链DNA抗体方面显示出重要作用。该文综述了DNASE1L3基因及编码蛋白Dnase1L3的特征、在SLE发病机制中的作用,以及DNASE1L3基因遗传学在SLE中的研究进展,为SLE遗传因素与免疫细胞的相关研究提供参考依据。

Research progress of deoxyribonuclease 1-like 3 gene and encoding protein in systemic lupus erythematosus

Genetic factors play an important role in the pathogenesis of systemic lupus erythematosus(SLE).The polymorphism of pathogenic sites and functional changes of coding proteins in SLE can lead to abnormal B cells,producing a large number of inflammatory factors and specific autoantibodies,and eventually lead to the loss of tolerance of B cells to DNA and(or)chromatin.deoxyribonuclease 1-like 3(DNASE1L3)gene and its coding protein Dnase1L3 play an important role in the degradation of DNA apoptotic particles and clearance of serum anti dsDNA antibodies.This paper reviews the characteristics of DNASE1L3 gene and its coding protein Dnase1L3,its role in the pathogenesis of SLE,and the research progress of DNASE1L3 genetics in SLE,so as to provide a reference for the study of SLE genetic factors and immune cells.