早发性卵巢功能不全患者辅助生殖药物预处理新进展

早发性卵巢功能不全(POI)是一种严重影响生育期女性身心健康的异质性疾病,发病机制不明.对于POI患者,目前尚缺乏有效手段来预防和(或)恢复其正常卵巢储备功能.对有生育需求的POI患者,适时或及时接受辅助生殖治疗可提高其妊娠率和活产率.行辅助生殖治疗前,对POI患者进行个体化生育力评估,采用多种预处理方案,能有效改善卵...

New Progress in Drug Pretreatment in Patients with Premature Ovarian Insufficiency

Premature ovarian insufficiency(POI) is a heterogeneous disease that seriously affects the physical and mental health of women during childbearing period. However, the pathogenesis of POI is still unknown. For patients with POI, there is no effective means to prevent and/or restore their normal ovarian reserve.For those POI patients with fertility needs, the timely assisted reproductive treatment can improve their pregnancy rate and live birth rate. Individual fertility assessment of POI patients before assisted reproductive therapy, using a variety of pretreatment regimens, can effectively improve the poor ovarian response(POR), increase the success rate of assisted reproduction and improve pregnancy outcome. This article reviewed the progress in the pretreatment with assisted reproductive drugs in POI patients, including hormonal drugs, antioxidant stress agents,immunomodulators, anticoagulants and metabolic regulators, in order to provide reference for the selection of individual treatment protocols. It is true that the pretreatment with assisted reproductive drugs in patients with POI is very important for improving the pregnancy outcome.