中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值对溃疡性结肠炎的诊断价值

目的探讨中性粒细胞/淋巴细胞比值(NLR)和血小板/淋巴细胞比值(PLR)在溃疡性结肠炎(UC)患者外周血中的水平,评估两者对UC的诊断效能。方法收集87例UC患者纳入UC组,收集65例肠易激综合征(IBS)患者纳入对照组。分析患者临床资料,比较两组NLR和PLR水平差异;采用Pearson相关分析NLR、PLR与临床常用指标白细胞计数(WBC)、血小板计数(PLT)、C反应蛋白(CRP)、红细胞沉降率(ESR)的相关性;采用受试者工作特征(ROC)曲线计算NLR和PLR最佳临界值及曲线下面积(AUC),并与常用炎性指标进行比较。结果UC组患者外周血NLR和PLR均明显高于对照组(P<0.05)。相关性分析发现,NLR、PLR均与WBC、CRP和ESR呈正相关(P<0.05)。NLR用于诊断UC的最佳临界值为2.64,灵敏度和特异度分别为81.9%和62.6%,AUC为0.758,PLR用于诊断UC的最佳临界值为163.40,灵敏度和特异度分别为75.0%和60.6%,AUC为0.759,两者均优于WBC(AUC:0.687)和PLT(AUC:0.745),稍逊于ESR(AUC:0.783)和CRP(AUC:0.830)。NLR联合CRP、PLR联合CRP对UC的诊断价值均优于CRP单独检测。结论NLR和PLR在UC患者外周血中的水平升高。NLR、PLR诊断UC的效能优于常用指标WBC和PLT,其与CRP联合应用可提高UC的诊断效能。

Clinical value of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in diagnosis of ulcerative colitis

Objective To investigate the levels of neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)in the peripheral blood of the patients with ulcerative colitis(UC),and to evaluate their diagnostic efficiency in diagnosing UC.Methods Eighty-seven patients with UC were enrolled in the study as the UC group,and 65 patients with irritable bowel syndrome(IBS)were included into the control group.The clinical data of the patients were analyzed.The differences of NLR and PLR levels were compared between the two groups.The correlations of NLR and PLR with clinical commonly used indicators such as WBC,PLT,CRP and ESR were assessed by adopting the Pearson correlation analysis.The ROC curve was used to calculate the optimal cut-off values and the area under curve(AUC)of NLR and PLR,and the results were compared with the commonly used inflammatory indicators.Results The peripheral blood NLR,PLR levels in the UC group were significantly higher than those in the control group(P<0.05).The correlation analysis found that NLR and PLR were positively correlated with WBC,CRP and ESR.The optimal cut-off value of NLR for diagnosing UC was 2.64,the sensitivity was 81.9%,the specificity was 62.6%,and AUC was 0.758.The optimal cut-off value of PLR for diagnosing UC was 163.40,the sensitivity and specificity were 75.0%and 62.6%respectively,and AUC was 0.759,they both were superior to WBC(AUC:0.687)and PLT(AUC:0.745),while which were slightly inferior to ESR(AUC:0.783)and CRP(AUC:0.830).The diagnostic values of NLR combined with CRP and PLR combined CRP were superior to that of single CRP detection.Conclusion The NLR and PLR levels in the peripheral blood of the patients with UC are increased.The efficiency of NLR and PLR for diagnosing UC is superior to that of common indicators WBC and PLT,its combined use with CRP can increase the UC diagnostic efficiency.