习惯性流产患者血清ENO1Ab、ACA、Tim-1的水平及意义

目的 探究抗α-烯醇化酶抗体(ENO1Ab)、抗心磷脂抗体(ACA)、T细胞免疫球蛋白域黏蛋白域蛋白-1(Tim-1)在习惯性流产(RSA)患者血清中的水平及意义.方法 选取2016年2月至2019年12月该院诊治的124例RSA患者为RSA组,选取同期该院体检健康的129例早孕女性作为健康对照组.采用酶联免疫吸附试验...

The level and significance of serum ENO1Ab,ACA and Tim-1 in patients with recurrent spontaneous abortion

Objective To investigate the levels and significance of anti-α-enolase antibody(ENO1Ab),anticardiolipin antibody(ACA)and T cell immunoglobulin domain mucin domain-1(Tim-1)in patients with recurrent spontaneous abortion(RSA).Methods Totally 124 cases of RSA patients treated in the hospital from February 2016 to December 2019 were selected as RSA group,and 129 healthy early pregnant women in the hospital during the same period were selected as healthy control group.Enzyme linked immunosorbent assay was used to detect the serum levels of ENO1Ab,ACA,IL-2 and IL-4,and real-time quantitative PCR was used to detect the serum Tim-1 level;the correlations between serum ENO1Ab,ACA,Tim-1 levels and IL-2,IL-4 were analyzed;and the influencing factors of RSA were analyzed.Results Reproductive tract infection,passive smoking during pregnancy,serum ENO1Ab,ACA,Tim-1,IL-2 levels in RSA group were significantly higher than those in healthy control group,and IL-4 level was significantly lower than that in healthy control group(P<0.05).Serum ENO1Ab,ACA and Tim-1 levels were positively correlated with IL-2 levels(r=0.587,0.473,0.456,P<0.05),and negatively correlated with IL-4 levels(r=-0.462,-0.515,-0.347,P<0.05),and serum ENO1Ab and ACA levels were positively correlated with Tim-1 level(r=0.467,0.465,P<0.05).Reproductive tract infection,high levels of ENO1Ab,ACA,TIM-1 and IL-2 were the risk factors of RSA(P<0.05),and high level of IL-4 was the protective factor(P<0.05).Conclusion The serum ENO1Ab,ACA and Tim-1 levels in RSA patients were significantly increaed,which may interact with IL-2 and IL-4,and then jointly affect the occurrence and development of RSA.