脑源性神经营养因子在子宫内膜异位症及其相关疼痛中的研究进展

子宫内膜异位症(EMs)是一种常见且影响广大育龄期女性的妇科良性疾病,该病的早期诊断和治疗是目前临床工作中亟需解决的难题.EMs有3种公认的病理类型,分别是腹膜型、卵巢型及深部浸润型.然而不论哪种病理类型,疼痛都是EMs患者最为突出的临床表现,包括经期腹痛、慢性盆腔痛及性交痛等不适,严重影响女性的身心健康,并增加经济负...

Research Progress of BDNF in Endometriosis and Related Pain

Endometriosis (EMs) is a common gynecological benign disease that affects the majority of women of childbearing age. The early diagnosis and treatment of EMs is an urgent problem in clinical work. There are three recognized pathological types of EMs: peritoneal type, ovarian type and deep invasive type. However, regardless of the pathological type, pain is the most prominent clinical manifestation of EMs patients, including menstrual abdominal pain, chronic pelvic pain and sexual intercourse pain, which seriously affects women′s physical and mental health and increases economic burden. Brain derived neurotrophic factor (BDNF) is one of the members of the neurotrophic protein family. It is not only widely distributed in the central and peripheral nervous system, but also widely distributed in the female reproductive system. It plays an important role in many pathophysiological processes, such as inflammatory reaction, tumor development, neuroangiogenesis and so on. BDNF is also an important regulator of pain formation and maintenance in various chronic diseases. It has been found that BDNF is highly expressed in serum and tissues of patients with EMs, and has gradually become a hot spot in EMs research.