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| 口服蒿甲醚控制重疫区血吸虫病及预防急性感染 | |
| 引用本文： | 陈红根,林丹丹,李岳生,刘跃民,黄兴华,冯正. 口服蒿甲醚控制重疫区血吸虫病及预防急性感染[J]. 中国血吸虫病防治杂志, 2006, 18(1): 32-35. DOI: 10.3969/j.issn.1005-6661.2006. |
| 作者姓名： | 陈红根 林丹丹 李岳生 刘跃民 黄兴华 冯正 |
| 作者单位： | 1. 江西省寄生虫病防治研究所,南昌,330046 2. 湖南省血吸虫病防治研究所 3. The QIMR,University of Queensland (Queensland 4029,Australia) 4. 江西省余干县血吸虫病防治站 5. 中国疾病预防控制中心寄生虫病预防控制所 |
| 基金项目： | WellcomeTrust(UK)InternationalCollaborativeResearchGrants(290238) |
| 摘 要： | 目的观察口服蒿甲醚控制日本血吸虫病重疫区人群感染及预防急性感染的效果.方法在鄱阳湖区血吸虫病易感季节(5～10月)对重疫区村居民采用15 d间隔口服蒿甲醚预防感染.同时设对照组,口服安慰剂.结果感染季节结束后,实验组人群粪检阳性率为0.83%,无急性感染发生;对照组粪检阳性率为15.01%,发生3例急性感染.结论每15天间隔口服蒿甲醚1次,对重疫区人群有良好的保护作用,保护率为94.47%,有利于控制人群感染;对防止急性感染也有明显效果. |
| 关 键 词： | 蒿甲醚 预防 血吸虫病 |
| 文章编号： | 1005-6661(2006)01-0032-04 |
| 收稿时间： | 2005-09-28 |
| 修稿时间： | 2005-09-28 |
Studies on effect of artemether to control infection and prevent acute infection of Schistosoma japonicum in high endemic areas |
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| Chen Honggen,Lin Dandan,Li Yuesheng,Liu Yuemin,Donald P.McManus,Huang Xinghua,Feng Zheng. Studies on effect of artemether to control infection and prevent acute infection of Schistosoma japonicum in high endemic areas[J]. Chinese journal of schistosomiasis control, 2006, 18(1): 32-35. DOI: 10.3969/j.issn.1005-6661.2006. | |
| Authors: | Chen Honggen Lin Dandan Li Yuesheng Liu Yuemin Donald P.McManus Huang Xinghua Feng Zheng |
| Affiliation: | 1. Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, China; 2. Hunan Provincial Institute of Parasitic Diseases, China; 3. The QIMR, University of Queensland, Queensland 4029, Australia; 4. Yugan Anti-schistosomiasis Station, China; 5. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, China |
| Abstract: | Objective To observe the effect of artemether in the control of prevalence and acute infection of Schistosoma japonicum in humans in high endemic areas. Methods During the transmission season (May-October), the residents in the pilot village took artemether with a 15- day interval to prevent the infection of S. japonicum. Results By the end of the transmission season, the egg positive rate was 0.83% and no acute case occurred in the artemether group, while 15.01% and 3 acute cases were observed in the placebo group. Conclusions Oral administration of artemether at a 15-day interval shows an effective protection from infection of S. japonicum, with a protection rate of 94.47% in residents of a high endemic area and it also shows marked effect to prevent acute schistosomiasis. |
| Keywords: | Artemether Prevention Acute schistosomiasis |
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