双氢克尿噻对分化型甲状腺癌术后残留甲状腺摄碘功能及辐射吸收剂量的影响

目的　探讨双氢克尿噻 (双克 )提高分化型甲状腺癌 (DTC)术后残留甲状腺摄碘功能及增强 1 31 I辐射吸收剂量的作用。方法　将 30例 DTC术后患者随机分为双克组与对照组 ,双克组给予双克 2 5 m g tid,连用 4 d,对照组给予安慰剂。两组均分别在给药前后测定 2 4 h甲状腺摄碘率、1 31 I有效半衰期 (Teff)、甲状腺激素水平及促甲状腺激素 (TSH)水平。结果　双克组用药后同用药前相比 ,2 4 h摄碘率提高至原来的 (1 .36± 0 .5 8)倍 ,辐射吸收剂量增强至原来的 (1 .35± 0 .5 4 )倍 ,Teff改变不明显 ,与对照组比较 ,2 4 h摄碘率显著提高 ,辐射吸收剂量显著增强。结论　双克有明显提高 DTC术后残留甲状腺摄碘功能、增强残留甲状腺 1 31 I辐射吸收剂量的作用

Randomized Controlled Trial of Hydrochlorothiazide in Augmenting the Dose of 131I Absorbed by Thyroid Remant

OBJECTIVE: Based on the rationale that the ablation of thyroid remnant can effectively reduce the risk for recurrence of differentiated thyroid carcinoma (DTC) and hence decrease the case fatality rate. This randomized controlled trial was designed to assess the value of hydrochlorothiazide in the ablation of thyroid remnant with 131I. METHODS: Thirty consecutive DTC patients with thyroid remnant after thyroid surgery were divided into two groups by randomization, the hydrochlorothiazide group received hydrochlorothiazide 25 mg tid for 4 days, the control group received placebo. Responses to treatment were evaluated by the increment of thyroid 131I uptake rate at 24 h and the augmentation of 131I absorbed dose. RESULTS: In the hydrochlorothiazide group, the 24 h 131I uptake rate was about (1.36+/-0.58) times larger than that before treatment, the absorbed dose was about (1.35+/-0.54) times larger than that before treatment. And in comparison with the control group, the 24 h 131I uptake rate of the hydrochlorothiazide group was significantly increased and the 131I absorbed dose was significantly augmented. CONCLUSION: Hydrochlorothiazide is effective for increasing 24 h 131I uptake rate and augmenting 131I absorbed dose of thyroid remnant.