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肝细胞癌:肝细胞和乙型肝炎病毒的共同进化
引用本文:何奕达, 陈宏森, 柳东红, 曹广文. 乙型肝炎病毒感染在非霍奇金淋巴瘤发生发展中的作用及机制[J]. 上海预防医学, 2022, 34(9): 935-942. DOI: 10.19428/j.cnki.sjpm.2022.22073
作者姓名:何奕达  陈宏森  柳东红  曹广文
作者单位:1.海军军医大学海军医学系流行病学教研室,上海 200433;2.海军军医大学第三附属医院肝外科,上海 200433
基金项目:国家自然科学基金(81520108021、91529305、81673250)
摘    要:

非霍奇金淋巴瘤(non⁃Hodgkin lymphoma,NHL)是免疫细胞的恶性肿瘤,包括B淋巴细胞、T淋巴细胞和NK细胞。病毒感染在NHL发生发展中具有重要作用,例如EB病毒(Epstein⁃Barr virus,EBV)和肝炎病毒等。乙型肝炎病毒(hepatitis B virus,HBV)感染通过基因整合、变异和病毒复制在肝细胞癌发生发展中的作用和机制已经得到比较深入的研究。载脂蛋白B mRNA编辑酶催化多肽(apolioprotein B mRNA⁃editing enzyme catalytic polypeptide,APOBEC)诱导的突变是HBV及宿主基因变异的来源之一,APOBEC家族成员在HBV相关慢性炎症和HBV及宿主基因组突变中起着桥梁作用。由此推测HBV感染在HBV相关NHL发生过程中发挥重要作用。本文从HBV整合、慢性炎症与免疫、病毒变异、信号通路、高频突变基因和表观遗传修饰等方面总结了HBV在NHL发生发展中的作用及机制,为HBV相关NHL研究提供理论依据。



关 键 词:乙型肝炎病毒  非霍奇金淋巴瘤  致病机制  癌症进化
收稿时间:2022-04-18

Epidemiology and etiology of leukemia and lymphoma
HE Yida, CHEN Hongsen, LIU Donghong, CAO Guangwen. Role and related mechanisms of hepatitis B virus infection in the development of non-Hodgkin lymphoma[J]. Shanghai Journal of Preventive Medicine, 2022, 34(9): 935-942. DOI: 10.19428/j.cnki.sjpm.2022.22073
Authors:HE Yida  CHEN Hongsen  LIU Donghong  CAO Guangwen
Affiliation:1.Department of Epidemiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China;2.Department of Hepatic Surgery,Third Affiliated Hospital, Naval Medical University, Shanghai 200433, China
Abstract:
Non-Hodgkin lymphoma (NHL) is a malignant tumor that occurs in immune cells, including B, T and NK cells. Viral infection, such as infection with Epstein-Barr virus (EBV) and hepatitis virus, plays an important role in the development of NHL. The role and mechanism of hepatitis B virus (HBV) infection in the development and progression of hepatocellular carcinoma through gene integration, mutation, and viral replication have been researched in depth. Mutations induced by apolioprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family members are one of the major sources of HBV and host genetic variation, and APOBEC family members act as bridges between HBV-related chronic inflammation and the mutations of HBV and its host genome. Therefore, we suspect that HBV infection plays a significant role in the occurrence of HBV-associated NHL. This review summarizes the role and mechanism of HBV in the occurrence and development of NHL from the aspects of HBV infection, chronic inflammation and immunity, viral variation, signaling pathways, high-frequency mutant genes and epigenetic modification, hoping to provide a theoretical basis for HBV-associated NHL research.
Keywords:hepatitis B virus  non-Hodgkin lymphoma  pathogenic mechanism  cancer evolution-development
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