An effective antimicrobial complex of nanoscale β-cyclodextrin and ciprofloxacin conjugated to a cell adhesive dipeptide |
| |
| Authors: | Reza Taheri-Ledari Farinaz Jalali Leili Heidari Fatemeh Ganjali Fereshteh Rasouli Asl Simindokht Zarei-Shokat Mohadeseh Forouzandeh-Malati Adibeh Mohammadi Ali Maleki |
| |
| Affiliation: | Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114 Iran.; Department of Chemistry, Faculty of Basic Sciences, Ilam University, P. O. Box 69315-516 Ilam Iran |
| |
| Abstract: | ![]()
Today, various drug delivery systems (DDS) are utilized to carry and deliver the desired drugs to the targeted action area to reduce potential side effects and negative interactions. Nanomaterials are an excellent candidate for the delivery of potent drugs, as they enhance pharmacokinetic and pharmacodynamic properties. Herein, we present a new ciprofloxacin (CPFX) delivery system based on a polymeric nanocarrier (β-cyclodextrin) conjugated to a cell-adhesive dipeptide structure. Cyclodextrin (CD) is an inexpensive, easily accessible, biodegradable, and biocompatible material. Also, the conjugation of cysteine–arginine (CR) dipeptide to the CPFX/β-CD particles is carried out to enhance cell adhesion growth. Through accurate analysis, the drug content and release for a final product have been estimated to be ca. 32%. Overall, the antimicrobial effects of CPFX were considerably raised through a low dose of CPFX. The growth zone inhibition of CPFX/β-CD–CR particles on the staphylococcus aureus and the Escherichia coli bacterial cells was 5.5 ± 0.2 cm and 3.5 ± 0.2 cm, respectively. Hence, this therapeutic nano bioconjugate is an excellent candidate to be applied in antimicrobial applications with the minimum incorporated CPFX.A soft-matter based antimicrobial nano-cargo made of beta-cyclodextrin and ciprofloxacin is reported. |
| |
| Keywords: | |
|
|
