丙型肝炎防治指南（2019年版）

了解浙江省台州市吸毒人群丙型病毒性肝炎（丙肝）的感染状况，分析其变化趋势及丙肝病毒（HCV）感染相关影响因素。

2009—2020年，每年4—8月在台州市吸毒人群监测哨点中随机抽取新纳入监测的400名吸毒者进行横断面研究。通过问卷调查，收集一般人口学、艾滋病相关知识、接受干预服务情况、毒品使用以及性行为相关情况等信息；同时采集其血液标本进行HCV抗体检测，以了解其感染状况。采用χ² 检验及多因素logistic回归分析HCV抗体阳性的危险因素。

2009—2020年，共纳入5 042名吸毒者，HCV抗体总阳性率为22.7%。
其中，2009—2019年HCV抗体阳性率由34.9%下降至8.8%，呈明显下降趋势（χ² =221.025，P<0.001），但是，2019—2020年HCV抗体阳性率为12.7%。多因素logistic回归分析的结果显示：年龄≥25岁、同居、吸食传统或混合型毒品、曾注射过毒品和共用针具是HCV感染的危险因素。

自2009年以来，台州市吸毒人群HCV感染率总体呈下降趋势，但在2020年略有上升。须针对吸毒人群丙肝感染情况继续监测，并结合相关影响因素加强综合防治。

Global hepatitis report

To determine the prevalence of hepatitis C virus （HCV） infection and identify the underlying risk factors among drug users in Taizhou City of Zhejiang Province during 2009‒2020.A consecutive cross-sectional survey was conducted. A total of 400 drug users in correctional settings were randomly selected from April to August. The drug users were interviewed with a questionnaire to collect demographic characteristics， AIDS-related knowledge， detoxification service， drug use， and sexual behavior. Blood samples were then collected for anti-HCV antibody testing. Chi-square test and multivariate conditional logistic regression were used.A total of 5 042 drug users were included in this study. Seroprevalence of HCV was determined to be 22.7%. From 2009 to 2019， the seroprevalence showed a significant downward trend， from 34.
9% to 8.8% （χ² =221.025， P<0.001）. However， in 2020， the seroprevalence was 12.7%. The multivariate logistic regression analysis showed that senior age （≥25 years old）， cohabitation， taking traditional or mixed drugs， injection drug use， and needle sharing were risk factors associated with HCV seroprevalence.Since 2009， HCV seroprevalence among drug users in Taizhou City has shown a downward trend， however， it has increased slightly in 2020. It warrants strengthening prevention and treatment measures in response to risk factors related to HCV infection among drug users.