老年性白内障中p33ING1和p53的表达及临床意义

目的探讨生长抑制基因p33ING1和肿瘤抑制基因p53在年龄相关性白内障晶状体上皮细胞中的表达，并初步探讨p33ING1和p53在年龄相关性白内障发病中的作用，进一步展望二者在年龄相关性白内障术后与后发障发生的相关性。方法30例年龄相关性白内障及10例透明晶状体前囊，应用免疫组织化学法，分别观察对照组和白内障组晶状体上皮细胞中p33ING1和p53的阳性表达水平：结果透明品状体组中p33ING1和p53极低表达，年龄相关性白内障组中p33ING1和p53高表达。、两组相比较，p33ING1和p53表达均有显著性差异（P〈0．05）。对白内障组进行p33ING1和p53相关性分析，二者有正相关关系。结论p33ING1和p53在年龄相关性白内障的形成过程中起重要作用，且二者具有协同作用。

The expression and significance of p33ING 1 and p53 in age-related cataract

Objective To confirm the expression of p33ING1 and p53 in age-related cataract lens epithelial cells and to investigate the relation between p33ING1 ,p53 and cataract. To expect the relationship between the p33ING1 , p53 and the accurance of after-cataract. Methods 10 cases of transparent lens epithelial cells and 30 cases of age-related cataracts lens epithelial cells from anterior capsule were studied. The expression of p33ING1 and p53 were examined by immunohistochemical technique. Results p33ING1 and p53 were negative in transparent lens epithelial cells. The expression of p33ING1 and p53 in cataract group were apparently positive. Both were sigificantly different from the control group （P 〈 0.05）. The expression of p33ING1 was correlated to that of p53. Conclusion p33ING1 and p53 may play an important role in agerelated catraract formation, and they have synergies.