肺结核患者氧化／抗氧化失衡的观察

目的观察肺结核患者氧化/抗氧化失衡的特点及相关影响因素。方法用比色法对20例正常对照者和120例肺结核患者血清的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、丙二醛（MDA）进行检测。结果与正常对照组相比，肺结核患者血清SOD、GPX活性降低，MDA含量增加（P＜0.01）。具有浸润、空洞、纤维化和/或毁损肺等多种影像学改变的肺结核患者以及红细胞沉降率增加的患者SOD、GPX进一步降低（P＜0.01），但MDA无显著性变化。卡方检验及logistic回归分析显示，影像学多种病变并存和红细胞沉降速度增快分别与SOD和GPX的降低密切相关（P＜0.01）。结论肺结核患者存在着氧化/抗氧化失衡，影像学多种病变并存和红细胞沉降速度增快分别与SOD和GPX的降低密切相关。

The study on the imbalance between oxidation and anti-oxidation in the patients with pulmonary tuberculosis

Objective To study the characteristic and influential factors of imbalance between oxidation and anti-oxidation of pulmonary tuberculosis（TB）. Methods The superoxide dismutase （SOD） ,glutathione peroxidase （GPX） and malonaldehyde（MDA） were detected in the sera from 20 healthy controls and 120 patients with pulmonary TB. Results 1. Compared with the healthy controls, the level of SOD,GPX decreased and MDA increased in pulmonary TB group（P〈0.01）. 2. The SOD,GPX decreased more obviously in the pulmonary TB patients with cavity or fibrosis and in the patients of faster erythrocyte sedimentation rate（P〈0. 01）, but no difference of MDA was observed between them. 3. Through the chi-square test and logistic regression, we found that the loss of SOD and GPX was associated with TB lesion＇s imageological characteristic and the patients＇ESR. Conclusions The patients with TB have the imbalance between oxidation and anti-oxidation, the loss of SOD and GPX was associated with TB lesion＇s imageological characteristic and the patients＇ ESR.