耐多药肺结核患者二线药敏试验结果分析

目的了解2006和2007年北京市耐多药病例菌株耐二线药物状况，为制定耐多药病例治疗方案提供依据。方法采用绝对浓度法对确定的43例耐多药菌株进行二线抗结核药物敏感试验。结果43例MDR-TB中XDR-TB占2.3%,耐LFX14%，耐AK,PAS,Pto均为9.3%,耐CM2.3%。69.8%的耐多药菌株对二线药敏感。结论对于耐多药病例，进行二线药敏试验，有利于耐多药结核病标准化方案和个体方案的制定。

The results of the second-line drug susceptibility testing in the MDR-TB patients

Objective To understand the M. tuberculosis resistance to 5 second-line anti-TB drugs in the MDR-TB patients from 2006 to 2007, and provide the evidence for making the treatment regimens. Methods The absolute concentration method was used in drug susceptibility testing with 5 second-line anti-TB drugs in 43 confirmed MDR-TB cases. Results In 43 MDR-TB cases, 2.3% was XDR-TB cases, 14% was resistant to LFX, 9.3% was resistant to AK, PAS and Pto respectively, and 2.3% was CM. 69.8% of the MDR-TB strains were sensitive to the 5 secondline anti-TB drugs. Conclusions The second-line anti-TB drug susceptibility testing will help us to make the standard and individual treatment regimens for the MDR-TB cases.