A Systematic Review and Meta-analysis of Survival and Surgical Outcomes Following Neoadjuvant Chemoradiotherapy for Pancreatic Cancer |
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Authors: | Jerome Martin Laurence Peter Duy Tran Kavita Morarji Guy D. Eslick Vincent Wai To Lam Charbel Sandroussi |
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Affiliation: | (1) Department of Surgery, University of Sydney, Blackburn Building D06, Sydney, NSW, 2006, Australia;(2) Royal Prince Alfred Hospital, Sydney, NSW, Australia;(3) Westmead Hospital, Sydney, NSW, Australia;(4) Liverpool Hospital, Sydney, NSW, Australia;(5) The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Sydney, NSW, Australia;(6) Surgical Outcomes Resource Centre (SOuRCe), The University of Sydney, Sydney, NSW, Australia |
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Abstract: | ![]()
Introduction This systematic review and meta-analysis aims to characterize the surgically important benefits and complications associated with the use of neoadjuvant chemoradiotherapy for the treatment of both resectable and initially unresectable pancreatic cancer. Studies were identified through a systematic literature search and analyzed by two independent reviewers. Survival, peri-operative complications, death rate, pancreatic fistula rate, and the incidence of involved surgical margins were analyzed and subject to meta-analysis. |
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