白细胞介素-18与急性冠脉综合征的相关性分析

目的 评估探讨白细胞介素-18与急性冠状动脉综合征的相关性.方法 研究对象为稳定型心绞痛患者（CCS组,36例）、急性冠脉综合征患者（ACS组）（共39例,3个亚组各13例）、正常健康成年人（对照组,38例）,ACS组根据冠状动脉造影确定的病变分支数又分为三组累及单支的ACS 1组,累及双支的ACS 2组,累及三支及以上的ACS 3组],共39例,各13例.采用酶联免疫吸附试验技术测定IL-18,并分析其与急性冠脉综合征患者的相关性.结果 与对照组比较,较高的血清IL-18水平出现在ACS 3组（P〈0.01）,其次依次分别为ACS 2组（P〈0.01）和ACS 1组（P〈0.05）,CCS组患者的血清IL-18水平与对照组相比无统计学差异（P〉0.05）.结论 IL-18可以作为急性冠脉综合征的观察指标,并且与病变分支数呈正性相关.

Study on relationship between interleukin -18 and acute coronary syndrome

Objective To explore the relationship between plasma level of interleukin - 18 （ IL - 18 ） with development of acute coronary syndrome （ACS）. Methods A total of 75 patients with coronary heart disease were divided into stable angina pectoris （CCS） group （n = 36）, acute coronary artery syndrome （ ACS1 ） group （ n = 13 ）, ACS2 group （ n = 13 ）, ACS3 group （ n = 13 ） and normal control group （ n = 38 ）. ACS group included 39 patients with acute coronary artery syndrome （ D - ACS ）, and they were divided into 3 groups according to number of identified lesions in branches of coronary angiography, 13 cases in each group respectively; in addition 38 healthy persons were randomly allocated in normal control group. By using ELISA technique for determination of interleukin -18 （IL -18） , and its relationship with D -ACS had been analyzed. Results Compared with control group, serum level of IL - 18 in group ACS3 was higher （ P 〈 0.01 ）, followed by ACS2 group （ P 〈 0.01 ） and group ACS1 （ P 〈0.05 ）, and serum level of IL - 18 in patients of CCS group compared with that of control group showed no significant difference （ P 〉 0.05）. Conclusion The level of IL - 18 can be applied for evaluation of the severity of coronary heart disease and it can be used as a serum marker for prediction of the occurrence of ACS.