IL-4R、IL-13、ADAM33基因多态性与中国皖南地区汉族人群支气管哮喘的相关性研究

目的:探讨IL-4受体基因Arg551Gln(rs1801275)、IL-13基因Arg130Gln(rs20541)、ADAM33基因T1(rs2280091)位点基因多态性与中国皖南地区汉族人群支气管哮喘的相关性。方法:采用病例-对照的方法,用聚合酶链反应及直接基因测序法比较116例支气管哮喘组与70例正常人对照组之间基因型、等位基因频率的差异。结果:哮喘组和对照组IL-4受体基因Arg551Gln位点和IL-13基因Arg130Gln位点的基因型和等位基因型频率的差异有统计学意义,ADAM33基因T1位点基因型哮喘组和对照组差异有统计学意义,等位基因型频率在哮喘组和对照组差异无统计学意义。结论:提示IL-4R Arg551Gln(rs1801275)位和IL-13基因Arg130Gln(rs20541)位的多态性可能与中国皖南地区汉族哮喘有相关性;ADAM33基因(rs2280091)T1位点位的多态性可能与中国皖南地区汉族哮喘无相关性。

Study on association between IL-4R,IL-13 and ADAM33 gene mutation and asthmatic patients of with Bronchial Asthma in Han nationality of Wannan Area

Objective:To investigate the association between polymorphism of IL-4R,IL-13,ADAM33 gene and asthma by analyzing genotypes and alleles frequency of IL-4R gene in loci of rs1801275,IL-13 gene rs20541 and ADAM33 gene rs2280091 from asthmatic people of Han nationality in Wanan,China.Methods:To determine the genotypes of IL-4R gene in loci of rs1801275,IL-13 gene rs20541 and ADAM33 gene rs2280091 were determined with polymerase chain reaction technique and direct gene sequencing analysis.Then the genotypes and ...