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| CD147蛋白和MMP-9在子宫腺肌病中的表达和意义 | |
| 引用本文： | 邹宁,任云青,李培莉,薛丽萍. CD147蛋白和MMP-9在子宫腺肌病中的表达和意义[J]. 中国免疫学杂志, 2011, 27(2): 144-148. DOI: 10.3969/j.issn.1000-484X.2011.02.011 |
| 作者姓名： | 邹宁 任云青 李培莉 薛丽萍 |
| 作者单位： | 1. 山西医科大学,太原,030001 2. 山西医科大学汾阳学院,汾阳,032200 3. 山西省汾阳医院妇产科,汾阳,032200 |
| 摘 要： | 目的:研究CD147蛋白、MMP-9在子宫腺肌病患者组织中的表达及血清中可溶性CD147(sCD147)蛋白水平,探讨其在子宫腺肌病中的作用机制。方法:采用免疫组织化学SP法检测37例子宫腺肌病患者(子宫腺肌病组)子宫异位内膜、在位内膜及20例子宫肌瘤患者(对照组)子宫内膜组织中CD147蛋白和MMP-9的表达,并对其蛋白表达量进行相关性分析;采用ELISA双抗体夹心法检测37例子宫腺肌病患者血清sCD147蛋白的水平,20例子宫肌瘤患者和20例女性健康体检者设为对照。结果:子宫腺肌病组异位与在位子宫内膜组织腺上皮细胞、间质细胞均有CD147蛋白、MMP-9表达,且明显高于对照组(P<0.01),其中异位内膜CD147蛋白、MMP-9表达量高于在位内膜(P<0.01);子宫腺肌病组CD147蛋白与MMP-9的表达量成正相关,对照组两者则无相关性。子宫腺肌病组血清sCD147蛋白的水平高于子宫肌瘤组(P>0.05)和健康体检者组(P<0.05)。结论:子宫腺肌病患者异位与在位内膜组织中CD147蛋白和MMP-9高表达及血清sCD147蛋白高水平可能与子宫腺肌病发生发展有关,且CD147蛋白可能通过促进MMP-9合成与分泌而发挥其作用。 |
| 关 键 词： | CD147 MMP-9 可溶性CD147 子宫腺肌病 |
Expression of CD147 protein and MMP-9 and the significance in patients with adenomyosis |
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| ZOU Ning,REN Yun-Qing,LI Pei-Li,XUE Li-Ping. Expression of CD147 protein and MMP-9 and the significance in patients with adenomyosis[J]. Chinese Journal of Immunology, 2011, 27(2): 144-148. DOI: 10.3969/j.issn.1000-484X.2011.02.011 | |
| Authors: | ZOU Ning REN Yun-Qing LI Pei-Li XUE Li-Ping |
| Affiliation: | ZOU Ning,REN Yun-Qing,LI Pei-Li,XUE Li-Ping.Shanxi Medical University,Taiyuan 030001,China |
| Abstract: | Objective:To study the expression of CD147 and MMP-9 protein in patients with adenomyosis as well as their serum levels of soluble CD147 in order to investigate their roles in the pathogenesis of adenomyosis.Methods:Immunohistochemistry was performed to detect the expression of CD147 and MMP-9 protein in ectopic endometrium and eutopic endometrial tissues of 37 patients with adenomyosis(AM group) and endometrial tissues of 20 patients only with hysteromyoma(control group).The correlation between the express... |
| Keywords: | CD147 MMP-9 Soluble CD147 Adenomyosis |
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