| 系统性红斑狼疮(SLE)患者家族人员的免疫学检查 |
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| 引用本文： | 文启治,肖伟平,赵述源,方佩芳.系统性红斑狼疮(SLE)患者家族人员的免疫学检查[J].武汉大学学报(医学版),1982(1). |
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| 作者姓名： | 文启治 肖伟平 赵述源 方佩芳 |
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| 作者单位： | 湖北医学院附一医院皮肤科，湖北医学院附一医院皮肤科，湖北医学院附一医院皮肤科，湖北医学院皮肤科免疫室 |
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| 摘 要： | <正> 在对SLE的研究中,越来越多的证据表明,SLE的发病与遗传因素有关。在临床上,SLE的遗传坝向也是比较突出的,同一家族中可能有2个以上的患者,有的还为双生甚至是同卵双生。有的亲属虽无显性症状,但可除出自身抗体或有其他血清蛋白异常。本实验的目的在于从测定与SLE患者有血缘关系的亲属的免疫学指标入手,以探讨SLE的发病与遗传因素的关系。
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IMMUNOLOGICAL EXAMINATUON OF FAMILIAL MENBERS OF CASES WITH SYSTEMIC LUPIS ERYTHEMATOSUS |
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| Abstract: | This article presents an immunological examination of 137 familial menbers of 26 cases with systemic lupus erythematosus. The method include: (1) Employing the indirect immunofluorecence test to determine the serum anti-nuclear antibody (ANA) . (2) Determining the serum C_3 and immunoglobulin value. The results were as follow. 1. The serum ANA titer was higher than 1:160 in 63 cases. Among them, 24 males and 39 femals. 2. The serum C_3 level was extremely lower than that of the controls (P<0.001). 3. The serum immunoglovulin level was normal ( P>0.05). |
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