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祛瘀化痰方对动脉粥样硬化大鼠血液流变学的影响
引用本文:许利平,杨鑫伟,李情琴,商硕,郭晶晶,刘凤琪,张楠,侯睿,陈敏,赵含森. 祛瘀化痰方对动脉粥样硬化大鼠血液流变学的影响[J]. 中华中医药学刊, 2014, 0(1): 10-12
作者姓名:许利平  杨鑫伟  李情琴  商硕  郭晶晶  刘凤琪  张楠  侯睿  陈敏  赵含森
作者单位:[1]首都医科大学中医药学院,北京100069 [2]首都医科大学附属北京中医医院,北京100010
基金项目:北京市中医药科技项目(JJ2009-17)
摘    要:目的:观察祛瘀化痰方对动脉粥样硬化大鼠血液流变学的作用。方法:采用维生素D3结合高脂饲料法建立大鼠动脉粥样硬化模型,经药物治疗8周后,取腹主动脉血测定血液流变学相关指标。结果:与模型对照组比较,祛瘀化痰方两个剂量组能显著降低血细胞比容(P<0.001),也能降低两个剂量组的血浆黏度和全血黏度的水平(P<0.05P<0.001),对高剂量组血浆纤维蛋白原含量也能明显降低(P<0.05),对血小板聚集有明显降低趋势,但无统计学意义(P>0.05)。结论:祛瘀化痰方可改善动脉粥样硬化大鼠血液流变学异常,阻止动脉粥样硬化病变发展。

关 键 词:祛瘀化痰方  动脉粥样硬化  血液流变学

Effect of Quyu Huatan Decoction on Hemorrheology in Atherosclerosis Rats
XU Liping,YANG Xinwei,LI Qingqin,SHANG Shuo,GUO Jingjing,LIU Fengqi,ZHANG Nan,HOU Rui,CHEN Min,ZHAO Hansen. Effect of Quyu Huatan Decoction on Hemorrheology in Atherosclerosis Rats[J]. Chinese Archives of Traditional Chinese Medicine, 2014, 0(1): 10-12
Authors:XU Liping  YANG Xinwei  LI Qingqin  SHANG Shuo  GUO Jingjing  LIU Fengqi  ZHANG Nan  HOU Rui  CHEN Min  ZHAO Hansen
Affiliation:1. Traditional Chinese Medicine School, Capital Medical University, Beijing 100069, China ; 2. Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010 ,China)
Abstract:Objective: To observe the effect of Quyu Huatan Decoction on hemorrheology in atherosclerosis rats. Methods : The atherosclerosis model in rats was established by feeding with vitamin D2 and rich fat food, and hemorrheolo- gy was measured from abdominal aortic blood of atherosclerosis rats after treating 8 weeks. Result : In both Quyu Huatan Decoction groups,hematocrit values were significantly lower than that of model control group ( P 〈0.001 ). Plasma vis- cosity and whole blood viscosity were significantly lower than that of model control group ( P 〈 0.05, P 〈 0. 001 ). Plas- ma fibrinogen of higher dosage group was significantly lower ( P 〈 0.05 ). Platelet aggregation seemed to be lower com- pared with model control group, but there was no significant ( P 〉 O. 05 ). Conclusion: Quyu Huatan Decoction can treat abnormal hemorrheology of atherosclerosis in rats to prevent the development of atherosclerotic pathological changes.
Keywords:Qutan Huayu Decoction  atberosclerosis  hemarheology
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