| RGD修饰载紫杉醇脂质体用于抗脑胶质瘤的体外研究 |
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| 引用本文： | 吴永红. RGD修饰载紫杉醇脂质体用于抗脑胶质瘤的体外研究[J]. 中南药学, 2014, 0(1): 22-24 |
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| 作者姓名： | 吴永红 |
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| 作者单位： | 广东省惠州市第三人民医院药学部,广东惠州516001 |
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| 摘 要： | 目的制备RGD修饰载紫杉醇脂质体并考察其体外抗脑胶质瘤治疗效果。方法采用薄膜分散法制备RGD修饰载紫杉醇脂质体（RGD—LP-PTX），考察其理化性质。用鼠源性脑胶质瘤c6细胞考察肿瘤细胞对脂质体的摄取效率。MTT实验考察脂质体对肿瘤细胞的增殖抑制率。结果制备得到的RGD—LP粒径在120nm左右，PD，〈0.3。C6细胞对RGD．LP的摄取能力显著〉LP；RGD-LP-PTX对C6细胞的生长的抑制作用显著强于LP。结论经过RGD修饰后，脂质体具有良好的脑胶质瘤细胞靶向性，且能够显著增强栽药脂质体对脑胶质瘤细胞的增殖抑制作用。
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| 关 键 词： | RGD 紫杉醇 脂质体 脑胶质瘤 |
Preparation of paclitaxel loaded RGD modified liposome and anti-glioma evaluation in vitro |
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| WU Yong-hong. Preparation of paclitaxel loaded RGD modified liposome and anti-glioma evaluation in vitro[J]. Central South Pharmacy, 2014, 0(1): 22-24 |
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| Authors: | WU Yong-hong |
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| Affiliation: | WU Yong-hong (Department of Pharmacy, Third Hospital of Huizhou, Huizhou Guangdong 516001) |
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| Abstract: | Objective To determine the antitumor effect of the novel paclitaxel （PTX） loaded RGD modified liposome （RGD-LP-PTX） on rat glioma cell line C6. Methods Liposome was prepared by film-ultrasonic method. Cellular uptake by C6 glioma cells was explored. The anti-proliferation efficiency of RGD-LP-PTX was evaluated by MTT assay. Results The evaluation of cell uptake showed RGD-LP-PTX was a good delivery system for glioma. The anti- proliferative activity against C6 confirmed strong inhibitory effect of the PTX loaded RGD modified liposome. Con- clusion RGD can enhance the cellular uptake of liposome by C6 cells and enhance the inhibition of C6 cells. |
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| Keywords: | RGD paclitaxel liposome glioma |
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