脐血胆红素预测新生儿病理性黄疸的价值

目的 探讨脐血胆红素水平预测足月健康新生儿病理性黄疸程度的价值.方法 采集足月新生儿2 ml脐静脉血,用氧化法测定胆红素.生后至出院每日上午8:00-9:00,采用经皮胆红素测量仪于新生儿前额部测定胆红素.比较不同脐血胆红素范围的新生儿病理性黄疸及治疗的比例.结果 257例新生儿中59例(22.96%)发生病理性黄疸,发生病理性黄疸脐血胆红素浓度[(39.68±8.10)μmol/L]显著高于未发生病理性黄疸脐血胆红素浓度[(30.05±5.51)μmol/L](P＜0.01).随着脐血胆红索浓度上升,高胆红素血症发生率增加(P＜0.01),需干预治疗的病例增多(P＜0.01).结论 脐血胆红素水平对预测新生儿病理性黄疸有极大价值,并为早期诊断和治疗提供可靠依据.

Abstract：

Objective To investigate the predictive value of umbilical cord blood bilirubin for pathological jaundice in healthy term newborns. Methods Two ml navel string vein blood of baby were collected after giving birth in the normal newborn, and the hemobilirubin was detected by accidentally oxidation method. After birth, the infant's bilirubin level was tested on the forehead by the transcutaneous bilirubinometer at 8:00 -9:00 every morning until discharging from hospital. The ration of pathological jaundice of newborn and its treatment were analyzed in different levels of cord blood hemobilirubin. Results Fifty-nine cases ( 22.96% ) with pathological jaundice were diagnosed in 257 newboms.The concentration of cord blood hemobilirubin in baby with pathological jaundice [(39.68 ±8.10) μmol/L] was significantly higher than that of the normal newborn [(30.05 ±5.51) μmol/L](P＜0.01). As the concentration of cord blood hemobilirubin was increased, the incidence of pathological jaundice was raised (P＜ 0.01), and the cases that needed to intervention treatment was increased(P＜ 0.01). Conclusion The detection of the level of cord blood hemobilirubin is not only very worthy to estimate the occurrence of pathological jaundice of newborn, but also offer reliable evidence for clinical early diagnosis and treatment.

Predictive value of umbilical cord blood bilirubin level for neonatal pathological jaundice

Objective To investigate the predictive value of umbilical cord blood bilirubin for pathological jaundice in healthy term newborns. Methods Two ml navel string vein blood of baby were collected after giving birth in the normal newborn, and the hemobilirubin was detected by accidentally oxidation method. After birth, the infant's bilirubin level was tested on the forehead by the transcutaneous bilirubinometer at 8:00 -9:00 every morning until discharging from hospital. The ration of pathological jaundice of newborn and its treatment were analyzed in different levels of cord blood hemobilirubin. Results Fifty-nine cases ( 22.96% ) with pathological jaundice were diagnosed in 257 newboms.The concentration of cord blood hemobilirubin in baby with pathological jaundice [(39.68 ±8.10) μmol/L] was significantly higher than that of the normal newborn [(30.05 ±5.51) μmol/L](P＜0.01). As the concentration of cord blood hemobilirubin was increased, the incidence of pathological jaundice was raised (P＜ 0.01), and the cases that needed to intervention treatment was increased(P＜ 0.01). Conclusion The detection of the level of cord blood hemobilirubin is not only very worthy to estimate the occurrence of pathological jaundice of newborn, but also offer reliable evidence for clinical early diagnosis and treatment.