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| VEGF-C及其受体VEGFR-3 mRNA在大肠癌的表达和意义 | |
| 引用本文： | 牟江洪,阎晓初,肖华亮,王东,李增鹏,段光杰,向德兵,张沁宏. VEGF-C及其受体VEGFR-3 mRNA在大肠癌的表达和意义[J]. 重庆医学, 2006, 35(3): 215-218 |
| 作者姓名： | 牟江洪 阎晓初 肖华亮 王东 李增鹏 段光杰 向德兵 张沁宏 |
| 作者单位： | 第三军医大学大坪医院野战外科研究所肿瘤中心病理科,重庆,400042;第三军医大学西南医院病理学研究所,重庆,400038 |
| 摘 要： | 目的研究大肠癌VEGF-C和VEGFR-3 mRNA的表达与大肠癌淋巴管生成的关系。方法采用RT—PCR检测32例新鲜大肠癌及相应正常组织中VEGF—C和VEGFR-3 mRNA表达，免疫组化染色淋巴管内皮特异标记物podoplanin计数淋巴管密度，以血管标记物CD34染色做对比。结果大肠癌VEGF—C及其受体VEGFR-3 mRNA水平显著高于正常组织，且二者表达具有显著正相关性。大肠癌VEGF-C mRNA高表达组癌周淋巴管密度显著高于低表达组。伴有淋巴管受累或淋巴结转移组VEGF-C mRNA显著高于无淋巴管受累或淋巴结转移组。结论VEGF-C／VEGFR-3信号转导途径可能对大肠癌癌周淋巴管生成具有重要作用，并可能进而促进癌组织淋巴结转移。 |
| 关 键 词： | 大肠癌 VEGF-C VEGFR-3 淋巴管生成 转移 |
| 文章编号： | 1671-8348(2006)03-0215-04 |
High expression of VEGF-C and VEGFR-3 mRNA and its implication in colorectal cancer |
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| MOU Jiang-hong,YAN Xiao-chu,XIAO Hua-liang,et al.. High expression of VEGF-C and VEGFR-3 mRNA and its implication in colorectal cancer[J]. Chongqing Medical Journal, 2006, 35(3): 215-218 | |
| Authors: | MOU Jiang-hong YAN Xiao-chu XIAO Hua-liang et al. |
| Abstract: | Objective To study the relationship of expression of VEGF-C and VEGFR-3 mRNA with lymphangiogenesis in colorectal cancer.Methods The mRNA expression of VEGF-C and its receptor VEGFR-3 in 32 cases with CRC were detected by RT-PCR.The microlymphatic density(MLD) and microvessel density(MVD) were evaluated by immunohistochemistry with anti-human podoplanin and CD34 antibody respectively.Results VEGF-C and VEGFR-3 mRNA level of tumor tissues was significantly higher than that in normal mucosa.Moreover,the mRNA expression of VEGF-C was significantly coincident and correlated with that of VEGFR-3.VEGF-C mRNA expression was significantly correlated with MLD at the edge of CRC and with lymphatic involvement and lymph nodes metastasis in CRCs.Conclusion VEGF-C/-D-VEGFR-3 signal pathway might play an important role in peritumoral lymphangiogenesis,and promote lymph node metastasis. |
| Keywords: | VEGF-C VEGFR-3 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |