经皮左心耳封堵的研究进展

心房颤动（房颤）在人群中的发病率逐年升高，成为临床中最常见的心律失常之一。脑栓塞是房颤最主要的并发症。抗凝治疗仍然是预防房颤脑卒中的主要手段，但无论是华法林还是新型抗凝药都有一定的局限性，存在相关的风险及禁忌，且依从性差。鉴于非瓣膜病性房颤患者90%以上的血栓来源于左心耳（LAA)，故对于一些栓塞风险高的房颤患者，经皮左心耳封堵术已成为长期华法林替代治疗以降低新发脑卒中风险的另一选择。

Research progress of percutaneous left atrial appendage clouser

The atrial fibrillation （AF） with increasing annual incidence has become one of the most common arrhythmia in clinical practice, with cerebral embolism being its major complication. Although anticoagulant therapy is still the principal means of prevention of cerebral apoplexy, both warfarin and other new anticoagulant drugs have some limitations and are often contraindicated or underutilized. Given that the left atrial appendage (LAA) has proved as the main position of thrombogenesis in patients with AF, percutaneous LAA closure is becoming a new choice of replacing warfarin in AF patients to reduce the risk of stroke.