复方苦参注射液治疗癌症疼痛患者90例疗效观察

目的探讨复方苦参注射液对晚期癌症疼痛的临床疗效。方法选取新入院的90例晚期癌症并疼痛患者，使用复方苦参注射液20ml加入250ml0．9氯化钠溶液或5％葡萄糖静脉滴注，40～60滴／min，每日1次，连用28d。观察轻、中、重度癌痛患者止痛效果、患者生活质量改善情况、不同中医证型患者疼痛改善情况及不良反应。结果不同癌痛分级患者疗效：轻度疼痛完全缓解（CR）率28．57％（10／35），部分缓解（PR）率54．29％（19／35），轻度缓解（MR）率5．71％（2／35），总有效率88．57％（31／35）；中度疼痛CR率10．00％（3／30），PR率23．33％（7／30），MR率36．67％（11／30j，总有效率70．00％（21／30）；重度疼痛PR率4．00％（1／25），MR率12．00％（2／25），总有效率16．00％（4／25）。90例癌痛患者生存质量改善：治疗前（21．04±4．92）分，治疗后（33．52±5．98）分，二者差异有统计学意义（t=14．07，P=0．00）。中医分型：90例癌痛患者中，痰瘀互结型最多，为26例（28．99％），脾肾阳虚最少，为10例（11．11％）；不同中医证型的癌痛缓解程度：痰瘀互结型总有效率最高，为88．46％（23／26），脾肾阳虚型总有效率最低，为20．00％（2／10）。全组病例只有1例出现皮疹，未发现消化道、骨髓、心、肝、肾等组织器官的不良反应。结论复方苦参注射液对轻、中度癌痛具有较好的止痛作用，并可改善患者生存质量，对痰瘀互结型疗效显著，为安全有效的中药制剂。

Therapeutic effect of complex radix sophorae flavescentis injection in treating cancer pain

Objective To evaluate the clinical effect of complex Radix Sophorae Flavescentis injection in treating advanced cancer pain. Methods 90 patients with advanced cancer and pain were selected randomly. The patients' general information was analyzed, their pain was ranked, and the score of quality of life was estimated. Results Among the patients with gentle pain,ratio of CR is 28.57 % (10/35), ratio of PR is 54.29 % (19/35), ratio of slight response is 5.71 %, total effective rate is 88.57 % (31/35). Among the patients with medium pain, the ratio of CR is 10% (3/30), ratio of PR is 23.33 % (7/30), ratio of slight response is 36.67 % (11/30), total effective rate is 70 % (21/30). Among the patients with severe pain, the ratio of CR is 0, ratio of PR is 4.00 % (1/25), ratio of slight response is 12.00 % (2/25), total effective rate is 16.00 % (4/25). The score of quality of life was improved from (21.04±4.92) to (33.52±5.98). The difference was statistical significant (t =14.07, P =0.00). TCM type: in all the 90 patients, the total effective rate of mixture of phlegm and blood phlegm are the highest (88.46 %), and the total effective rate of yang asthhenia of the spleen and kidney is 20.00 %. Rash was found in only one patient and no other adverse effect, such as in digestive tract, bone marrow, heart, liver or kidney was found among all patients. Conclusion Complex Radix Sophorae Flavescentis injection has significant analgesic effect in treating light and medium cancer pain and could improve the patients' quality of life, and it has significant therapeutic effect especially in the mixture of phlegm and blood stasis patients. So Complex Radix Sophorae Flavescentis injection is safe and effective traditional Chinese medical drug.