α7烟碱乙酰胆碱受体基因与精神分裂症及吸烟行为的关系 |
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引用本文: | 李彩霞,王强,邓伟,马小红,王英成,刘协和,李涛.α7烟碱乙酰胆碱受体基因与精神分裂症及吸烟行为的关系[J].中华精神科杂志,2011,44(2):75-78. |
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作者姓名: | 李彩霞 王强 邓伟 马小红 王英成 刘协和 李涛 |
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作者单位: | 1. 深圳市宝安区慢性病防治院 2. 四川大学华西医院心理卫生中心,成都,610041 |
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基金项目: | 国家自然科学基金资助项目,国家科技部"973"项目 |
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摘 要: | 目的 探讨α7烟碱样乙酰胆碱受体(nAchR)基因多态性与精神分裂症及吸烟行为的关系.方法 连续收集符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的精神分裂症患者221例(患者组)和患者亲属432名(亲属组),评定患者吸烟情况;采用聚合酶链反应和限制性酶切技术,检测α7nAchR基因的rs1355920单...
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关 键 词: | 精神分裂症 吸烟 基因 受体 烟碱 |
Association study of a7 nicotinic acetylcholine receptor subunit gene with schizophrenia and smoking |
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Abstract: | Objective To investigate the associations of two polymorphisms in α7 nicotinic acetylcholine receptor subunit gene(α7 nAchR)with schizophrenia and smoking.Methods Eligible patients with schizophrenia(n=221)according to the Diagnostic and Statistical Manual of Mental Disorders Fouah Edition(DSM-IV)and their healthy relatives(n=432)were continuously recruited.Smoking data were collected in the patients.Two polymorphisms(rs1355920 and D15S1360)of α7 nAchR gene were genotyped using PCR-RFLP.Associations of the polymorphisms with schizophrenia and smoking were analyzed using transmission disequilibrium tests(TDT)and haplotype analysis.Results The odds of patient group received from parents allele A of SNP rs1355920 was increased(Z=2.56,P=0.010),and the odds of received allele G was decreased(Z=-2.70,P=0.007).The allele A of rs1355920 was more common in the patients than in the relatives(x2=6.910,P=0.008).The frequencies of D15S1360 were not significantly different between patients and relatives(x2=1.33 1,P=0.5 14).The haplotypes of the two locus were related to schizophrenia(x2=6.991,P=0.030).In addition,all these alleles or genotype frequencies of rs1355920 and D15S1360 did not differ significantly between smokers and non-smokers(P>0.05).Conclusion The α7nAchR gene may be associated with schizophrenia.but not with smoking. |
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Keywords: | Schizophrenia Smoking Genes Receptors nicotinic |
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