| 电刺激大鼠上矢状窦旁硬脑膜后血浆降钙素基因相关肽和P物质的变化 |
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| 引用本文： | 董钊,姜磊,于生元. 电刺激大鼠上矢状窦旁硬脑膜后血浆降钙素基因相关肽和P物质的变化[J]. 中国康复理论与实践, 2011, 17(4): 334-336 |
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| 作者姓名： | 董钊 姜磊 于生元 |
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| 作者单位： | 解放军总医院神经内科,北京市,100853 |
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| 摘 要： | 目的观察电刺激上矢状窦旁硬脑膜对大鼠血浆降钙素基因相关肽(CGRP)和P物质浓度的影响。方法 13只大鼠随机分为对照组(n=6)和电刺激组(n=7)。对照组行假刺激,电刺激组以20 Hz、4 mA和250μs的方波电流刺激上矢状窦旁硬脑膜,使用放射免疫法比较血浆CGRP和P物质的浓度。结果对照组与电刺激组的血浆CGRP浓度相比有显著性差异(50.60±7.16 pg/ml vs 42.20±4.82 pg/ml,P=0.029),而血浆P物质浓度相比无显著性差异(308.59±43.07 pg/ml vs 264.60±60.28pg/ml,P=0.165)。结论电刺激上矢状窦旁硬脑膜能够降低大鼠血浆CGRP浓度,而P物质浓度无明显变化。
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| 关 键 词： | 电刺激 上矢状窦 降钙素基因相关肽 P物质 大鼠 |
Changes of Plasma Concentration of Calcitonin Gene-related Peptide and Substance P after Electrical Stimulation on Dura Mater Adjacent to Sinus Sagittalis Superior in Rats |
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| DONG Zhao,JIANG Lei,YU Sheng-yuan. Changes of Plasma Concentration of Calcitonin Gene-related Peptide and Substance P after Electrical Stimulation on Dura Mater Adjacent to Sinus Sagittalis Superior in Rats[J]. Chinese Journal of Rehabilitation Theory and Practice, 2011, 17(4): 334-336 |
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| Authors: | DONG Zhao JIANG Lei YU Sheng-yuan |
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| Affiliation: | DONG Zhao,JIANG Lei,YU Sheng-yuan.Department of Neurology,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | |
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| Keywords: | electrical stimulation superior sagittal sinus calcitonin gene related peptide substance P rats |
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