马来酸桂哌齐特联合阿加曲班治疗急性脑梗死的临床效果

目的研究马来酸桂哌齐特联合阿加曲班治疗急性脑梗死的效果。方法将89例急性脑梗死患者随机分为对照组(45例,阿加曲班)和观察组(44例,阿加曲班+马来酸桂哌齐特)。比较两组的临床效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的NIHSS评分均降低,ADL评分均升高,且观察组优于对照组(P<0.05)。治疗后,两组的血清NT-proBNP、MCP-1、sICAM-1、TNF-α水平均降低,IL-10水平均升高,且观察组优于对照组(P<0.05)。治疗后,两组的全血黏度(中切)、血小板聚集率和纤维蛋白原水平均降低,且观察组低于对照组(P<0.05)。结论马来酸桂哌齐特联合阿加曲班能提高急性脑梗死患者的疗效,改善其神经功能、血液流变学和血清细胞因子水平。

Clinical effect of cinepazide maleate combined with agatroban on acute cerebral infarction

Objective To study the effect of cinepazide maleate combined with agatroban on acute cerebral infarction.Methods A total of 89 patients with acute cerebral infarction were randomly divided into control group(45 cases,agatroban)and observation group(44 cases,agatroban+cinepazide maleate).The clinical effects of the two groups were compared.Results The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).After treatment,NIHSS scores of the two groups decreased,ADL scores increased,and those in the observation group were better than the control group(P<0.05).After treatment,the levels of NT-proBNP,MCP-1,sICAM-1,TNF-αin the two groups decreased,and IL-10 levels increased,and those in the observation group were better than the control group(P<0.05).After treatment,the whole blood viscosity(middle-shear),platelet aggregation rate and fibrinogen level of the two groups reduced,and those in the observation group were lower than the control group(P<0.05).Conclusion Cinepazide maleate combined with agatroban can improve the curative effect,nerve function,hemorheology and levels of serum cytokines of patients with acute cerebral infarction.