盐酸氨溴索与多索茶碱联合治疗慢性支气管炎急性发作的临床效果

目的分析盐酸氨溴索与多索茶碱联合治疗慢性支气管炎(CBC)急性发作的临床效果。方法选取2018年2月至2019年2月我院收治的108例CBC急性发作期患者作为研究对象,对其临床资料进行回顾性分析,按照治疗方式的不同将患者分为对照组和观察组,每组54例。对照组给予盐酸氨溴索治疗,观察组给予盐酸氨溴索联合多索茶碱治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组的VC、PEF、FEV1及FEV1/FVC均增高,且观察组显著高于对照组(P<0.05)。治疗后,两组的TNF-α、IL-8、IL-6、PCT、CRP水平均下降,且观察组显著低于对照组(P<0.05)。治疗后,两组的症状、活动能力评分均下降,且观察组显著低于对照组(P<0.05)。结论盐酸氨溴索与多索茶碱联合治疗CBC急性发作的效果显著,能够有效改善患者炎性因子水平和肺功能,促进了患者生活质量水平的提高,值得临床推广应用。

Clinical effect of ambroxol hydrochloride combined with doxofylline in the treatment of acute attack of chronic bronchitis

Objective To analyze the clinical effect of ambroxol hydrochloride combined with doxofylline in the treatment of acute attack of chronic bronchitis(CBC).Methods From February 2018 to February 2019,108 patients with acute attack of CBC admitted in our hospital were selected as research objects,and the clinical data were analyzed retrospectively.The patients were divided into control group and observation group according to different treatment methods,with 54 cases in each group.The control group was given ambroxol hydrochloride treatment,and the observation group was given ambroxol hydrochloride combined with doxofylline treatment.The treatment effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the VC,PEF,FEV1 and FEV1/FVC of the two groups increased,and those in the observation group were significantly higher than the control group(P<0.05).After treatment,the levels of TNF-α,IL-8,IL-6,PCT and CRP in the two groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the symptoms and activity scores of the two groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).Conclusion Ambroxol hydrochloride combined with doxofylline in the treatment of acute attack of CBC has a significant effect.It can effectively improve the level of inflammatory factors and pulmonary function of patients,and promote the improvement of patients'quality of life,which is worthy of clinical promotion and application.