Human neutrophil kinetics: a call to revisit old evidence |
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| Affiliation: | 1. Department of Respiratory Medicine, University Medical Center Utrecht, The Netherlands;2. Center for Translational Immunology, University Medical Center Utrecht, The Netherlands;3. Department of Immunology, University Medical Center Utrecht, The Netherlands;1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA;1. Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada;2. Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada;3. Department of Laboratory Medicine and Pathobiology, University of Toronto, ON M5S 1A8, Canada;4. Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA;1. Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA;1. Harvard-MIT Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA;2. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA;1. Division of Biological Sciences, University of California, San Diego, CA 92093, USA |
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| Abstract: | ![]()
The half-life of human neutrophils is still controversial, with estimates ranging from 7–9 h to 3.75 days. This debate should be settled to understand neutrophil production in the bone marrow (BM) and the potential and limitations of emergency neutropoiesis following infection or trauma. Furthermore, cellular lifespan greatly influences the potential effect(s) neutrophils have on the adaptive immune response. We posit that blood neutrophils are in exchange with different tissues, but particularly the BM, as it contains the largest pool of mature neutrophils. Furthermore, we propose that the oldest neutrophils are the first to die following a so-called conveyor belt model. These guiding principles shed new light on our interpretation of existing neutrophil lifespan data and offer recommendations for future research. |
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